Title:Nanofibers: New Insights for Drug Delivery and Tissue Engineering
Volume: 17
Issue: 13
Author(s): Mohammad Karim Haidar and Hakan Eroglu*
Affiliation:
- Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, P.O. Box: 06100, Ankara,Turkey
Keywords:
Nanofiber, Drug Delivery, Pharmaceutical Applications, Tissue Engineering, Drug release kinetics, Chemotherapeutic
agents.
Abstract: Nanofibers became one of the major research areas for drug delivery and tissue engineering
applications in the last decade. Depending on the simplicity of the preparation method and high
drug loading capacity, nanofibers provide many advantages for therapeutic perspectives. In addition,
combined systems such as embedding nanoparticles into the nanofiber structures provide a second
option for delivery of dual active ingredients in the same formulation. The release rate of the active
ingredients can also be modified easily by the formulation parameters depending on the desired release
time for treatment. Nanofibers systems are used for the delivery of antibiotics, anticancer drugs,
analgesics, hemostatic agents and various proteins for tissue engineering purposes. In addition, various
applications such as medical device coating also provide new insights for the clinical use of nanofibers.
The most commonly used technique for preparation of nanofibers is the electrospinning,
which provides feasibility background for scale up process from laboratory to the industrial applications.
The main boundary for nanofibers is the limitations for systemic route. Nanofibers are mainly
designed for the delivery of active ingredients for local purposes. Regardless of the therapeutic aim,
nanofibers are also perfect 3 dimensional structures that are suitable for tissue regeneration. They
provide matrix structure for cell regeneration especially in applications for wound healing. This review
is mainly focused on the recent advances on the preparation of nanofibers, applications for drug
delivery, tissue engineering and wound healing purposes.
