Abstract
Introduction: Fourteen novel 8,8-dimethyl-8,9-dihydro-5H-chromeno[2,3-d]pyrimidin-6(7H)- one derivatives were rationally designed and synthesized successfully. The synthetic procedures adopted for the target molecules were achieved by facile protocols and the yields were good to excellent (> 80%).
Method: All the synthesized compounds were characterized by 1H NMR, 13C NMR, HR-MS and FT-IR spectral analysis. All new compounds were evaluated for their in vitro antioxidant activity by using DPPH, ABTS, NO and H2O2 methods. Results: Among the novel derivatives, two of the synthesized compounds exhibited good antioxidant activities similar to ascorbic acid, in all the four tested methods.Keywords: Pyrimidines, synthesis, anti-oxidant activity, simple method, in vitro studies, human body.
Letters in Drug Design & Discovery
Title:Novel Chromeno[2,3-d]pyrimidines-Design, Synthesis and Antioxidant Activity
Volume: 14 Issue: 7
Author(s): Kotiah Yalagala, Sreekantha B. Jonnalagadda*, Suresh Maddila, Surjyakanta Rana and Surya Narayana Maddila
Affiliation:
- School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban-4000,south africa
Keywords: Pyrimidines, synthesis, anti-oxidant activity, simple method, in vitro studies, human body.
Abstract: Introduction: Fourteen novel 8,8-dimethyl-8,9-dihydro-5H-chromeno[2,3-d]pyrimidin-6(7H)- one derivatives were rationally designed and synthesized successfully. The synthetic procedures adopted for the target molecules were achieved by facile protocols and the yields were good to excellent (> 80%).
Method: All the synthesized compounds were characterized by 1H NMR, 13C NMR, HR-MS and FT-IR spectral analysis. All new compounds were evaluated for their in vitro antioxidant activity by using DPPH, ABTS, NO and H2O2 methods. Results: Among the novel derivatives, two of the synthesized compounds exhibited good antioxidant activities similar to ascorbic acid, in all the four tested methods.Export Options
About this article
Cite this article as:
Yalagala Kotiah, Jonnalagadda B. Sreekantha*, Maddila Suresh, Rana Surjyakanta and Maddila Narayana Surya, Novel Chromeno[2,3-d]pyrimidines-Design, Synthesis and Antioxidant Activity, Letters in Drug Design & Discovery 2017; 14 (7) . https://dx.doi.org/10.2174/1570180814666161123143637
DOI https://dx.doi.org/10.2174/1570180814666161123143637 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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