Title:The Relationship Between Systemic Lupus Erythematosus Activity and Persistent Positive Antiphospholipid Antibodies
Volume: 14
Issue: 2
Author(s): Zhaleh Shariati Sarabi, Maryam Sahebari, Ali Etemad Rezaie, Mohammad Taghi Norouzi, Kamila Hashemzadeh*Zahra Mirfeizi
Affiliation:
- Rheumatic Diseases Research Center (RDRC), Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
Keywords:
Antiphospholipid antibodies, systemic lupus erythematosus, autoimmune disorder, SLEDAI, IgG-aCL antibody.
Abstract: Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder, characterized
by producing different auto-antibodies and multiorgan involvements. In this study we aimed
to investigate the relationship between SLE activity and persistently positive antiphospholipid antibodies.
Objective/Methods: Fifty-nine lupus patients (55 women and 4 men) who were assessed in two
consecutive visits with 6 weeks interval were selected. Patients` clinical and laboratory data and
serum antiphospholipid antibodies` values, were collected. Serum anticardiolipin antibodies and
lupus anticoagulant were measured in two visits. The correlations between these antibodies with
SLEDAI and with major organ involvements were assessed.
We found that SLEDAI was significantly higher in persistently positive aPLs patients compared
with persistently negative aPLs patients. A positive correlation between IgG-aCL antibody titer and
SLEDAI at first visit (P=0.049) was also seen.
Result and Conclusion: The results showed that disease activity in SLE was associated with increased
APAs and persistent positive antiphospholipid antibodies may indicate higher lupus disease
activity.
