Abstract
Activation of the N-methyl-D-aspartate (NMDA) receptor would induce rapid opening of an ion channel permeable to Ca2+ ions across cell membranes, followed by an increase in the concentration of free Ca2+ ions in the cytoplasm and subsequent signaling cascade from the cytoplasm to the nucleus for consolidation of a transient extracellular signal carried by L-glutamate in the central nervous system. Both neuronal plasticity and cell death have been shown to involve intracellular free Ca2+ ions incorporated through this receptor-operated cation channel in the brain. On the other hand, iron is also abundant in the brain, with an essential role in mechanisms underlying maintenance of cellular integrity and function. Ferrous ions are believed to participate in neuronal cell death through generation of reactive oxygen species in ischemic brain injuries, for instance, while ferrous but not ferric ions are shown to block the influx of Ca2+ ions across NMDA receptor channels in cultured neurons. In this review article, we will summarize the possible relationship between iron and NMDA receptor channels in mechanisms associated with neuronal cell death in brains with ischemia.
Keywords: nmda receptors, ferrous ions, ischemia
Current Neurovascular Research
Title: Relevant Modulation by Ferrous Ions of N-Methyl-D-Aspartate Receptors in Ischemic Brain Injuries
Volume: 1 Issue: 5
Author(s): Noritaka Nakamichi, Hirotaka Oikawa, Yuki Kambe and Yukio Yoneda
Affiliation:
Keywords: nmda receptors, ferrous ions, ischemia
Abstract: Activation of the N-methyl-D-aspartate (NMDA) receptor would induce rapid opening of an ion channel permeable to Ca2+ ions across cell membranes, followed by an increase in the concentration of free Ca2+ ions in the cytoplasm and subsequent signaling cascade from the cytoplasm to the nucleus for consolidation of a transient extracellular signal carried by L-glutamate in the central nervous system. Both neuronal plasticity and cell death have been shown to involve intracellular free Ca2+ ions incorporated through this receptor-operated cation channel in the brain. On the other hand, iron is also abundant in the brain, with an essential role in mechanisms underlying maintenance of cellular integrity and function. Ferrous ions are believed to participate in neuronal cell death through generation of reactive oxygen species in ischemic brain injuries, for instance, while ferrous but not ferric ions are shown to block the influx of Ca2+ ions across NMDA receptor channels in cultured neurons. In this review article, we will summarize the possible relationship between iron and NMDA receptor channels in mechanisms associated with neuronal cell death in brains with ischemia.
Export Options
About this article
Cite this article as:
Nakamichi Noritaka, Oikawa Hirotaka, Kambe Yuki and Yoneda Yukio, Relevant Modulation by Ferrous Ions of N-Methyl-D-Aspartate Receptors in Ischemic Brain Injuries, Current Neurovascular Research 2004; 1 (5) . https://dx.doi.org/10.2174/1567202043361910
DOI https://dx.doi.org/10.2174/1567202043361910 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Glycogen Synthase Kinase-3 (GSK-3) Inhibitors for the Treatment of Alzheimers Disease
Current Pharmaceutical Design Anti-Inflammatory Therapy for Alzheimer’s Disease from Epidemiological Fact to New Mechanisms of Action
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry In Vitro Neuronal Induction of Adipose-Derived Stem Cells and their Fate after Transplantation into Injured Mouse Brain
Current Medicinal Chemistry Inhibitors of Endocannabinoid Degradation as Potential Therapeutic Agents: An Update
Medicinal Chemistry Reviews - Online (Discontinued) The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges
Current Pharmaceutical Design Chemometric Modeling of 5-Phenylthiophenecarboxylic Acid Derivatives as Anti-Rheumatic Agents
Current Computer-Aided Drug Design The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration
Current Neuropharmacology Current Development in Encapsulated Cell Therapy for Degenerative Retinopathies
Current Tissue Engineering (Discontinued) 2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth
Anti-Cancer Agents in Medicinal Chemistry Patented In Vitro Blood-Brain Barrier Models in CNS Drug Discovery
Recent Patents on CNS Drug Discovery (Discontinued) Double-Faced Role of Human Mesenchymal Stem Cells and their Role/Challenges in Cancer Therapy
Current Stem Cell Research & Therapy Nanotechnology Platforms in Diagnosis and Treatment of Primary Brain Tumors
Recent Patents on Nanotechnology A Study of Tryptophan Metabolism via Serotonin in Ventricular Cerebrospinal Fluid in HIV-1 Infection Using a Neuroendoscopic Technique
Current HIV Research TRPM8: From Cold to Cancer, Peppermint to Pain
Current Pharmaceutical Biotechnology Novel Therapeutic Targets in Neuropsychiatric Disorders: The Neuroepigenome
Current Pharmaceutical Design Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice
Current Neuropharmacology Carnitine Metabolism and Deficit - When Supplementation is Necessary?
Current Pharmaceutical Biotechnology Poly(ADP-ribose)polymerase Inhibition - Where Now?
Current Medicinal Chemistry Sub-Chronic Exposure of Non-Observable Adverse Effect Dose of Terbufos Sulfone: Neuroinflammation in Diabetic and Non-Diabetic Rats
CNS & Neurological Disorders - Drug Targets HCV-Related Central and Peripheral Nervous System Demyelinating Disorders
Inflammation & Allergy - Drug Targets (Discontinued)