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摘要
背景:阿尔茨海默病(AD)是最广泛的年龄相关的神经变性疾病。最近,越来越多的证据表明植物化学用减缓AD的发病和进展。 目的:回顾植物化学对AD治疗的潜在作用。 方法:从现有文献中对用于治疗AD患者的植物化学物质进行系统评价。选择标准包括:1)年龄≥60岁; 2)AD诊断符合国家老年痴呆症协会(NIAAA)的标准,3)适当的措施来评估认知功能和临床状态。 结果:本研究共纳入97篇文章。几种植物化学物质似乎减缓AD发作,延缓疾病进展,并通过抗胆碱能,抗氧化和抗炎功能来针对多种病理原因进行恢复。 结论:植物化学物质及其特定分子靶点的深入了解对于保证安全使用这些化合物作为AD治疗的选择至关重要。
关键词: 植物化学物质,阿尔茨海默病,抗氧化性能,抗炎活性,乙酰胆碱酯酶抑制剂,AChEIs
Current Drug Targets
Title:Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review
Volume: 18 Issue: 13
关键词: 植物化学物质,阿尔茨海默病,抗氧化性能,抗炎活性,乙酰胆碱酯酶抑制剂,AChEIs
摘要: Background: Alzheimer's disease (AD) is the most widespread age-related neurodegenerative disease. Recently, a growing body of evidence suggested the phytochemical use to slow down AD onset and progression.
Objective: To review the phytochemical role potentially involved in AD treatment. Method: A systematic review from existing literature on phytochemicals used in the treatment of AD patients was conducted. Selection criteria included: 1) age≥60 years; 2) AD diagnosis in agreement with the criteria of National Institute on Aging-Alzheimer's Association (NIAAA), and 3) suitable measures to asses cognitive, functional and clinical status. Results: Ninety-seven articles were involved in the present study. Several phytochemicals seem to slow down AD onset, delay disease progression and let recovery through targeting multiple pathological causes by anti-cholinergic, antioxidant and anti-inflammatory features. Conclusion: Deeper knowledge on phytochemicals and their specific molecular targets is essential to guarantee safe use of these compounds as an option for AD treatment.Export Options
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Cite this article as:
Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161102121553
DOI https://dx.doi.org/10.2174/1389450117666161102121553 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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