摘要
背景:基于性染色体的特异表达,男性和女性之间的生物学差异,不同的基因表达和特殊的性激素,导致生理学和病理生理学的重要差异。 目的:这项工作的目的是简要回顾抗血栓治疗中性别相关差异与临床意义之间的关系,可能与血小板生物学和凝血反应的性别差异有关。 结果:抗凝血药物参与治疗的主要临床条件是心房颤动,静脉血栓栓塞,冠状动脉疾病和外周动脉疾病。考虑到一致性证据表明,一方面,人类血小板活性可能受性别和性激素的影响,另一方面,雌激素可能对凝血蛋白基因的转录调控起关键作用,真正影响性别有关的差异的原因仍不清楚。此外,女性和男性对抗血栓药物呈现不同的反应,反映出药代动力学特征中的特征差异以及每种性别的生理特征。因此,抗血栓药物的功效和不良反应可能因性别而异。 结论:在止血和血栓形成的病理生理机制中可以报告几种性别相关的差异。此外,几个数据记录了抗血栓形成管理和临床有效性的性别差异。还需要进一步的研究来完全阐明这些问题。
关键词: 性别,血小板活性,凝血系统,抗血栓治疗,抗血小板药物,口服抗凝治疗,维生素K拮抗剂,NOAC
Current Medicinal Chemistry
Title:A Focused Review of Gender Differences in Antithrombotic Therapy
Volume: 24 Issue: 24
关键词: 性别,血小板活性,凝血系统,抗血栓治疗,抗血小板药物,口服抗凝治疗,维生素K拮抗剂,NOAC
摘要: Background: The biological differences among male and female, based on distinctive expression of sex chromosomes, on varied gene-expression and on peculiar sexual hormones, lead to important differences in physiology and pathophysiology.
Objective: The aim of this work was to briefly review the relationships among genderrelated differences and clinical implications in antithrombotic therapy, that could be related to sex-differences in platelet biology and coagulation reactions. Results: The major clinical setting in which antithrombotic drugs are involved for the treatment are atrial fibrillation, venous thromboembolisn, coronary artery disease and peripheral artery diseases. Considering that a consistent body of evidences suggests that, on one hand, human platelet activity may be influenced by sex and sex hormones and, on the other hand, estrogens are likely to play a crucial role on the transcriptional regulation of coagulation protein genes, the real impact of gender-related differences is still unclear. Moreover, women and men present different responses to antithrombotic drugs, reflecting genderspecific variances in pharmacokinetic profile, along with the physiological characteristics of each gender. Thus, the efficacy and adverse effects of antithrombotic drugs may vary according to gender. Conclusion: Several gender-related differences could be reported in haemostasis and thrombosis pathophysiological mechanisms. Moreover, several data documented relevant gender differences in antithrombotic management and clinical effectiveness. Further studies are still needed to completely elucidate these issues.Export Options
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Cite this article as:
A Focused Review of Gender Differences in Antithrombotic Therapy, Current Medicinal Chemistry 2017; 24 (24) . https://dx.doi.org/10.2174/0929867323666161029223512
DOI https://dx.doi.org/10.2174/0929867323666161029223512 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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