Title:Antioxidant Properties of Pyrimidine and Uracil Derivatives
Volume: 21
Issue: 20
Author(s): Irena Kostova*Petar Yordanov Atanasov
Affiliation:
- Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000,Bulgaria
Keywords:
Free radicals, antioxidants, pyrimidine, uracil, biological molecules, oxidative damage.
Abstract: Background: Free radicals are frequently generated in vivo and their reactivity varies causing different
damages to biological molecules, e.g. DNA, lipids, and proteins. Oxidative stress in the human body is
due to the free radicals generation and to the reduced level of antioxidants. Antioxidants are able to reduce the
risk for chronic diseases. Hence, natural and synthetic antioxidants may be predominantly significant in diminishing
cumulative oxidative damage.
Objective: Many novel approaches have been made and significant progress has been done in the last years.
This review shows current trend in the synthesis of pyrimidines and uracils and reveals their potent structures
which can be a good source for the synthesis of new derivatives with required antioxidant activity.
Conclusion: These classes of compounds play an essential role in a variety of biological systems and have substantial
attention in the field of pharmacology.
