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摘要
背景:地中海饮食包括橄榄油作为主要的脂肪来源。由于其生物活性和健康影响,这种饮食常常与长寿和慢性疾病的发生率相关。除了油酸之外,橄榄油还含有许多生物活性成分,据报道其中包括发挥抗氧化和抗炎活性的多酚。多酚可能部分地对与橄榄油相关的心血管疾病的保护作用负责。 目的:回顾和讨论有关羟基酪氨酸作用的可用文献作为心脏保护剂。此外,我们还讨论了羟基酪醇的化学方面,营养方面和生物利用度。 结果:羟基酪醇是橄榄油中主要的酚类化合物之一,具有强烈的自由基清除特性。为了进一步研究多酚羟基酪氨酸与动物试验和体外心血管事件和疾病的关系,已经进行了几项研究。然而,尽管有些人正在研究橄榄油或橄榄叶提取物的性质,但没有临床试验集中在羟基酪醇和心血管疾病的具体作用。 结论:来自橄榄油的羟基酪醇在体外和动物模型中具有抗氧化,抗炎,抗血小板聚集和致动脉粥样硬化活性。然而,其在人类中可能的治疗用途需要额外的临床试验。
关键词: 油橄榄油,橄榄油,心血管疾病,多酚,动脉粥样硬化,抗氧化剂。
Current Drug Targets
Title:Cardioprotective Effects of the Polyphenol Hydroxytyrosol from Olive Oil
Volume: 18 Issue: 13
关键词: 油橄榄油,橄榄油,心血管疾病,多酚,动脉粥样硬化,抗氧化剂。
摘要: Background: The Mediterranean diet includes olive oil as its primary source of fat. This diet is frequently associated to longevity and a lower incidence of chronic diseases due to its biological activities and health effects. Apart from oleic acid, olive oil contains many bioactive components including polyphenols that have been reported to exert antioxidant and anti-inflammatory activities. Polyphenols may almost in part be responsible for the protective effects against cardiovascular diseases associated with olive oil.
Objective: To review and discuss the available literature on hydroxytyrosol effects as a cardioprotective agent. Moreover, we also discuss the chemistry, nutritional aspects and bioavailability of hydroxytyrosol. Results: Hydroxytyrosol is one of the major phenolic compounds in olive oil and has demonstrated strong radical-scavenging properties. Several studies have been performed in order to look further into the effects of the polyphenol hydroxytyrosol in relation to cardiovascular events and illnesses in animal trials and in vitro. However, no clinical trials have focused on the specific action of hydroxytyrosol and cardiovascular diseases, although some are being undertaken to look at olive oil or olive leaf extract properties. Conclusion: Hydroxytyrosol from olive oil exerts antioxidant, anti-inflammatory, anti-platelet aggregation and ati-atherogenic activities in in vitro and animal models. However, its possible therapeutic use in humans requires additional clinical trials.Export Options
About this article
Cite this article as:
Cardioprotective Effects of the Polyphenol Hydroxytyrosol from Olive Oil, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161005150650
DOI https://dx.doi.org/10.2174/1389450117666161005150650 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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