摘要
背景:随着人口老龄化,社会经济成本巨大,神经退行性疾病越来越不可避免。世界卫生组织(WHO)报道说,到2040年,心血管疾病后,神经退行性疾病将超过癌症,成为死亡的第二大原因。 目的:本文综述了鞣花素类,一类可水解单宁,用于治疗和治疗神经退行性疾病的神经保护作用和临床意义。 结果:最近的研究表明,基因和环境毒素的组合可能有助于发展神经退行性疾病的风险。因此,旨在减少风险因素(如生活方式,吸烟,饮食,维生素缺乏,化学物质暴露和污染)的干预策略是有必要的。作为缓解或减弱神经元变性进展的治疗策略,包括鞣花素在内的膳食成分的调节已经成为近几十年来关注的焦点。 结论:多酚植物植物化学成分和鞣花素特别包含一系列神经保护性质,可用于改善人体健康,防止神经变性。
关键词: 抗氧化剂,鞣花素,神经变性,精神疾病,多酚
Current Drug Targets
Title:Neuroprotective Effects of Ellagitannins: A Brief Review
Volume: 18 Issue: 13
关键词: 抗氧化剂,鞣花素,神经变性,精神疾病,多酚
摘要: Background: Neurodegenerative diseases are increasingly inevitable as the population gets older, with enormous socio-economic costs. The World Health Organization (WHO) has reported that by 2040, neurodegenerative diseases will overtake cancer to become the second leading cause of death, after cardiovascular disease.
Objective: Herein, this review outlines the neuroprotective effects and clinical implications of ellagitannins, a class of hydrolysable tannins, for the management and treatment of neurodegenerative disorders. Results: Recent investigations suggest that the combination of genes and environmental toxins may contribute to the risk of developing neurodegenerative disorders. Thus, intervention strategies aimed at reducing exposure to risk factors such as life style, smoking, diet, vitamin deficiencies, chemical exposure and pollution are warranted. Modulation of dietary components including ellagitannins, as a therapeutic strategy to slow down or attenuate the progression of neuronal degeneration has become a focus of interest in the last few decades. Conclusion: Polyphenolic plant phytochemicals and ellagitannins in particular, contain an array of neuroprotective properties useful to improve human health and protect against neurodegeneration.Export Options
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Cite this article as:
Neuroprotective Effects of Ellagitannins: A Brief Review, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161005112002
DOI https://dx.doi.org/10.2174/1389450117666161005112002 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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