摘要
性是影响药理反应的几个因素之一,虽然对药代动力学和药效学的研究影响显着,但不完善,并且包含许多方法问题。 在这次审查中,评估了药物动力学中性别差异的现状以及对药物基因组学的一些暗示。 此外,考虑到通过生物标志物监测的许多药理学反应,已经报道了性别对某些生物标志物的影响。 最后,我们报告了药物动力学中的性别差异,特别是分析了阿片类药物及其在怀孕,劳动和哺乳期间的使用效果。 总之,为精确的基于性别的方法,似乎有必要对于在男性和女性中进行更多循证治疗。
关键词: 性别差异,药代动力学,药效学,生物标志物,阿片样物质,怀孕。
Current Medicinal Chemistry
Title:Sex Impact on Biomarkers, Pharmacokinetics and Pharmacodynamics
Volume: 24 Issue: 24
关键词: 性别差异,药代动力学,药效学,生物标志物,阿片样物质,怀孕。
摘要: Sex is one of several factors influencing pharmacological responses, but research on its effects on pharmacokinetics and pharmacodynamics, although emerging remarkably, remains poor and contains many methodological issues. In this review, the current state of knowledge about sex differences in pharmacokinetics and some hints to pharmacogenomics were evaluated. Moreover, considering that many pharmacological responses are monitored through biomarkers, the influence of sex on some biomarkers has been reported. Finally, we report sex differences in pharmacodynamics, particularly analysing opioids and their use during pregnancy, labor and breastfeeding. In conclusion, a more precise sex- and genderbased approach appears necessary to achieve more evidence-based therapy in men and women.
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Cite this article as:
Sex Impact on Biomarkers, Pharmacokinetics and Pharmacodynamics, Current Medicinal Chemistry 2017; 24 (24) . https://dx.doi.org/10.2174/0929867323666161003124616
DOI https://dx.doi.org/10.2174/0929867323666161003124616 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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