摘要
癌症是体内细胞失控生长,被认为是全球死亡的主要原因之一。有几种化疗药物如氨甲喋呤、5-氟尿嘧啶、顺铂、阿霉素和他莫昔芬等用于治疗癌症。虽然我们已经花费了数十亿美元用研究开发癌症化疗药物,它仍然是人类主要的疾病,部分原因是由于这些疗法的缺点。这些缺点包括靶向特异性低,严重的副作用(由于高剂量)和不足的药代动力学。为了避免这些缺点,抗癌药物传递系统已利用纳米载体包括脂质体,胶束聚电解质胶囊和其他载体。一最近研究用于化疗的纳米粒子的几类金属有机骨架(MOFs)是一种由金属离子和有机配体所组成的聚合物。MOFs材料已应用于气体分离、气体储存、催化、发光材料、生物医学成像等诸多领域。这些结构还有其他的功能,促进其作为药物载体在生物医学领域的使用。首先,他们是无毒的,可生物降解的,由于其多孔性而能进行高负荷的抗肿瘤剂。此外,他们有明确的晶体结构,其特征在于可以通过不同的分析技术,它们的大小是合适的,以控制其在体内的药物释放。 本文综述了合成MOFs的新方法以及其作为抗肿瘤药物载体的新应用。
关键词: 癌症,化疗,金属有机骨架(MOFs),加载,释放细胞毒性。
Current Medicinal Chemistry
Title:Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)
Volume: 24 Issue: 2
Author(s): Mihad Ibrahim, Rana Sabouni, Ghaleb A. Husseini.
Affiliation:
关键词: 癌症,化疗,金属有机骨架(MOFs),加载,释放细胞毒性。
摘要: Cancer is the uncontrolled growth of cells in the body and is considered as one of the major causes of death globally. There are several cytotoxic chemotherapeutic agents used to treat cancer including methotrexate, 5-fluorouracil, cisplatin, tamoxifen, doxorubicin and others. Although billions of dollars have been spent on cancer research to develop these chemotherapies, it still remains a major illness for mankind partly due to the shortcomings of these therapies. These shortcomings include low targeting specificity, severe side effects (due to high doses) and poor pharmacokinetics. To avoid these drawbacks, anti-cancer drug delivery systems have been developed recently using nanocarriers including liposomes, micelles, polyelectrolyte capsules and others.
One of the recent class of nanoparticles investigated for chemotherapeutic use are metal organic frameworks (MOFs) which are hybrid polymers that consist of metal ions or clusters and organic ligands. MOFs are used in many applications including gas/vapor separation, gas storage, catalysis, luminescent materials, and biomedical imaging. These structures have additional features that promote their use as drug carriers in the biomedical field. First, they are nontoxic, biodegradable and have the ability to carry high loadings of the anti-neoplastic agent due to their porous nature. Also, they have well-defined crystalline structures that can be characterized by different analytical techniques and their sizes are suitable to control their in vivo drug release.
This paper reviews the methods used to synthesize MOFs and their recent use as antineoplastic drug delivery carriers.
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Cite this article as:
Mihad Ibrahim, Rana Sabouni, Ghaleb A. Husseini. , Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs), Current Medicinal Chemistry 2017; 24 (2) . https://dx.doi.org/10.2174/0929867323666160926151216
DOI https://dx.doi.org/10.2174/0929867323666160926151216 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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