Abstract
Photodynamic therapy has many treatment applications for malignant and premalignant lesions of the skin. The basic principle involves application of a photosensitizer followed by exposure of the target tissues to light. 5-aminolevulinic acid is a natural occurring compound in the heme biosynthesis pathway. Its metabolite protoporphyrin IX is a photosensitizer that has the ability to selectively damage premalignant, malignant, and certain abnormal tissues, rendering its wide application for use in actinic keratosis, Bowen’s disease, and basal cell carcinoma. Adequate lesion preparation is critical for successful treatment. Ongoing research on the clinical use of photodynamic therapy, its potential impact in oncological patient management and on public health and cost is continuously evolving. The perfection of this light therapy on patient treatment awaits results of future clinical trials.
Keywords: Non-melanoma, photodynamic therapy, photosensitizers, skin cancer, treatment.
Current Cancer Therapy Reviews
Title:Photodynamic Therapy: The Light Treatment for Cutaneous Non- Melanoma Malignancies
Volume: 12 Issue: 2
Author(s): Edward Yu
Affiliation:
Keywords: Non-melanoma, photodynamic therapy, photosensitizers, skin cancer, treatment.
Abstract: Photodynamic therapy has many treatment applications for malignant and premalignant lesions of the skin. The basic principle involves application of a photosensitizer followed by exposure of the target tissues to light. 5-aminolevulinic acid is a natural occurring compound in the heme biosynthesis pathway. Its metabolite protoporphyrin IX is a photosensitizer that has the ability to selectively damage premalignant, malignant, and certain abnormal tissues, rendering its wide application for use in actinic keratosis, Bowen’s disease, and basal cell carcinoma. Adequate lesion preparation is critical for successful treatment. Ongoing research on the clinical use of photodynamic therapy, its potential impact in oncological patient management and on public health and cost is continuously evolving. The perfection of this light therapy on patient treatment awaits results of future clinical trials.
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Cite this article as:
Yu Edward, Photodynamic Therapy: The Light Treatment for Cutaneous Non- Melanoma Malignancies, Current Cancer Therapy Reviews 2016; 12 (2) . https://dx.doi.org/10.2174/1573394712666160919104726
DOI https://dx.doi.org/10.2174/1573394712666160919104726 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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