摘要
山楂(Crataegus oxyacantha L.)(同义词C. rhipidophylla Gand。)(Rosac-eae)是欧洲药典中两种药用认可的山楂树种之一。根据其低聚原花青素,需要从植物的浆果和花中制备的提取物的标准化。 C. oxyacantha因其用于治疗各种心脏问题而闻名,特别是在心脏功能下降的情况下心力衰竭,相当于纽约心脏病协会分类I期和II期,心绞痛,高血压伴心肌功能不全,轻度改变心律和动脉粥样硬化。据报道,C.oxyacantha发挥其他几种药理活性,如降血压,抗高血脂,抗高血糖,抗焦虑,免疫调节和抗突变。植物中存在低聚原花青素和黄酮/黄酮醇类黄酮,它们被认为是活性物质,酚酸,三萜,脂肪酸和甾醇的主要基团。本综述旨在概述C. oxyacantha的强心作用及其简短的植物化学。大量实验和临床研究通过各种机制强调了植物的心血管功效,包括正性肌力作用和负性变时作用,冠状动脉血流和运动耐量的升级,酶的抑制,如血管紧张素转换酶(ACE)和磷酸二酯酶,抗炎和抗高血脂作用,改善抗氧化酶的状态等,支持其心脏功效。该植物具有多种其他人类健康生物活性,通常伴随着其丰富的多酚含量。
关键词: 山楂,心脏活性,原花青素,类黄酮,生物活性。
Current Medicinal Chemistry
Title:Phytochemical and Pharmacological Activity Profile of Crataegus oxyacantha L. (Hawthorn) - A Cardiotonic Herb
Volume: 25 Issue: 37
关键词: 山楂,心脏活性,原花青素,类黄酮,生物活性。
摘要: Crataegus oxyacantha L. (syn. C. rhipidophylla Gand.) (Rosac-eae) is one of the two medicinally recognized hawthorn species in European Pharmacopeia. Standardization of the extract prepared from the berry and flowers of the plant is required according to its oligomeric procyanidins. C. oxyacantha is well-known for its use in the treatment of various heart problems particularly, including heart failure in cases of declining cardiac performance equivalent to stages I and II of the New York Heart Association classification, angina pectoris, hypertension with myocardial insufficiency, mild alterations of cardiac rhythm, and atherosclerosis. C. oxyacantha has been reported to exert several other pharmacological activities such as hypotensive, antihyperlipidemic, antihyperglycemic, anxiolytic, immunomodulatory, and antimutagenic. Oligomeric procyanidins and flavone/flavonol types of flavonoids, which are considered to be the chief groups of active substances, phenolic acids, triterpenes, fatty acids, and sterols are present in the plant. The present review aims mainly to outline cardiotonic effect of C. oxyacantha as well as its brief phytochemistry. Numerous experiments and clinical studies have underlined cardiovascular efficacy of the plant through various mechanisms including positive inotropic and negative chronotropic effects, escalation in coronary blood flow and exercise tolerance, inhibition of the enzymes such as angiotensinconverting enzyme (ACE) and phosphodiesterase, anti-inflammatory and antihyperlipidemic effects, improving status of antioxidant enzymes, etc., which support its cardioactive efficacy. The plant possesses several other bioactivities for human health usually concomitant to its rich polyphenolic content.
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Phytochemical and Pharmacological Activity Profile of Crataegus oxyacantha L. (Hawthorn) - A Cardiotonic Herb, Current Medicinal Chemistry 2018; 25 (37) . https://dx.doi.org/10.2174/0929867323666160919095519
DOI https://dx.doi.org/10.2174/0929867323666160919095519 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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