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Abstract
Background: In recent years, colloidal delivery systems based on nano-emulsion are gaining popularity; being used for encapsulation and delivery of many drugs. This review therefore aims at summarizing various methods of nano-emulsion formulation and their use as a topical and transdermal delivery vehicle for a number of active pharmaceutical ingredients from different pharmacological classes.
Methods: This article represents a systematic review of nano-emulsions for topical and transdermal drug delivery. A vast literature was searched and critically analysed. Results: Nano-emulsions are thermokinetically stable dispersion systems, which have been used in topical and transdermal delivery of a number of pharmaceutically active compounds. Nano-emulsions have a narrow droplet size range with tuneable surface properties, which make them an ideal delivery vehicle. Nanoemulsions have a number of advantages over conventional emulsions, including easy preparation using various low and high energy methods, optical transparency, high solubilisation capacity, high stability to droplet aggregation and the ability to penetrate the skin; thus allowing the transdermal delivery of drugs. Conclusion: This review indicated that nano-emulsions are promising vehicle for entrapping various drugs and are suitable for traversing the skin barrier for systemic effects.Keywords: Emulsification, micro-emulsions, nano-emulsions, skin permeation, topical drug delivery, transdermal drug delivery.
Current Drug Delivery
Title:Traversing the Skin Barrier with Nano-emulsions
Volume: 14 Issue: 4
Author(s): Cornel Burger, Yasser Shahzad, Alicia Brummer, Minja Gerber*Jeanetta du Plessis
Affiliation:
- Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520,south africa
Keywords: Emulsification, micro-emulsions, nano-emulsions, skin permeation, topical drug delivery, transdermal drug delivery.
Abstract: Background: In recent years, colloidal delivery systems based on nano-emulsion are gaining popularity; being used for encapsulation and delivery of many drugs. This review therefore aims at summarizing various methods of nano-emulsion formulation and their use as a topical and transdermal delivery vehicle for a number of active pharmaceutical ingredients from different pharmacological classes.
Methods: This article represents a systematic review of nano-emulsions for topical and transdermal drug delivery. A vast literature was searched and critically analysed. Results: Nano-emulsions are thermokinetically stable dispersion systems, which have been used in topical and transdermal delivery of a number of pharmaceutically active compounds. Nano-emulsions have a narrow droplet size range with tuneable surface properties, which make them an ideal delivery vehicle. Nanoemulsions have a number of advantages over conventional emulsions, including easy preparation using various low and high energy methods, optical transparency, high solubilisation capacity, high stability to droplet aggregation and the ability to penetrate the skin; thus allowing the transdermal delivery of drugs. Conclusion: This review indicated that nano-emulsions are promising vehicle for entrapping various drugs and are suitable for traversing the skin barrier for systemic effects.Export Options
About this article
Cite this article as:
Burger Cornel, Shahzad Yasser, Brummer Alicia, Gerber Minja*, du Plessis Jeanetta, Traversing the Skin Barrier with Nano-emulsions, Current Drug Delivery 2017; 14 (4) . https://dx.doi.org/10.2174/1567201813666160824125444
DOI https://dx.doi.org/10.2174/1567201813666160824125444 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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