恶性疟原虫 - 蛋白法呢基转移酶抑制剂作为抗疟药物靶点的综述

Title:A Review on Plasmodium falciparum-Protein Farnesyltransferase Inhibitors as Antimalarial Drug Targets

Volume: 18 Issue: 14

关键词: 恶性疟原虫，抗疟疾，蛋白质，法呢基转移酶，抑制剂

摘要: Background: Protein farnesyltransferase (PFT) inhibitors have emerged as a potent target for the malaria treatment caused by the Plasmodium falciparum (Pf) parasite.

Objective: To explore the various scaffolds which are active against Pf-PFT target.

Result: Seven inhibitor scaffolds based on ethylenediamine, peptidomimetic, benzophenone, benzamide, tetrahydroquinoline, naphthyridine and oxy-tetrahydroquinoline, have been developed till date.

Conclusion: It is concluded that naphthyridine based drugs are the most promising one. Furthermore, introducing the hydrophobic molecules like isoprenyl groups to a protein or a chemical compound facilitate protein-protein and protein-membrane interactions thereby makes them good candidates as new therapeutics. The future research should focus on the disease rather than the infection and the dynamics of its transmission; this will bring a new vision about the disease.

Cite this article as:

A Review on Plasmodium falciparum-Protein Farnesyltransferase Inhibitors as Antimalarial Drug Targets, Current Drug Targets 2017; 18 (14) . https://dx.doi.org/10.2174/1389450117666160823165004