摘要
个体化治疗在肿瘤疾病中的定义能够提高促进治疗成功率。因此,为了筛选出在该疾病早期辅助性中受益的患者以及在先进的病理期更好的定义和治疗临床或者治疗性的群体需要生物标记物。细胞因子网络的生理失调直接参与肿瘤的发生与发展。细胞活素在免疫系统的调节中起主要作用,但是它们很少单独释放,每种细胞活素都能够诱导许多其他因素的产生,并进一步形成一个网络能够与其他细胞调节因子如荷尔蒙和神经肽。基于这些原因为了鉴定真实的有效的药物靶点和标记物,研究必须直接评估不同细胞活素和他们单独的通路的相互作用以及对疾病原因和进展的贡献。TCD4+辅助细胞(Th)有不同的亚群,分别是能产生细胞活素的Th1、Th2、Th3、Th9和Th17。现在弄明白这些细胞活素网络的相互作用能产生肿瘤性疾病。此外,集中性别的研究已经表明免疫系统的动态平衡由把不同性别以及性别差异所定义的细胞活素的通路控制。因此,本人为了鉴定新的临床策略和个体化的治疗旨在强调这些细胞活素通路的重要性
关键词: 个体化治疗、肿瘤治疗、药物靶向和生物标记物、细胞因子生理网络、性别特异性细胞因子
Current Drug Targets
Title:The Role of Gender-specific Cytokine Pathways as Drug Targets and Gender- specific Biomarkers in Personalized Cancer Therapy
Volume: 18 Issue: 4
关键词: 个体化治疗、肿瘤治疗、药物靶向和生物标记物、细胞因子生理网络、性别特异性细胞因子
摘要: The definition of personalized treatments in tumor disease could lead to an improvement of the therapeutic success rate. Therefore, biomarkers are urgently required in order to select the patients that could benefit from adjuvant therapies in the initial phase of the disease and to better define and treat the clinical/therapeutic subgroups in the advanced pathological phases. Disregulation of cytokine physiological network is directly involved in the genesis and progression of tumors. Cytokines are of central importance in the regulation of immune system, but they are rarely released singly: each cytokine is able to induce the production of many other factors leading to a network in which they cooperate with other cell regulators such as hormones and neuropeptides. For these reasons the research must be directed to the evaluation of the interrelationships between the different cytokines and their respective pathways, as well as their contribution to the disease aetiology and progression in order to identify real and effective drug targets and biomarkers. The T CD4+ helper cells (Th) have various subpopulations, among which Th1, Th2, Th3, Th9 and Th17, respectively produce cytokines. It has become clear that disorders within the interactions of the network of these cytokines can produce neoplastic diseases. Furthermore, studies focusing on gender have shown that the homeostasis of the immune system is controlled by pathways of cytokines that are different between sexes and defined for this reason “genderspecifics”. Therefore, this perspective article aims to highlight the significance of these cytokine pathways in order to identify new clinical strategies and personalized therapy in neoplastic diseases.
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Cite this article as:
The Role of Gender-specific Cytokine Pathways as Drug Targets and Gender- specific Biomarkers in Personalized Cancer Therapy, Current Drug Targets 2017; 18 (4) . https://dx.doi.org/10.2174/1389450117666160630173647
DOI https://dx.doi.org/10.2174/1389450117666160630173647 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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