摘要
呼出的一氧化氮(NO)来源于上呼吸道,并在不同程度上对调节,保护和防御,以及有害过程都有一定的作用。一氧化氮在人体的生理和病理过程如血管调节、抗菌活性、神经递质和呼吸具有重要作用。本文总结了有关上呼吸道NO的来源、生物学和相关性研究。此外,我们讨论了NO在起源于鼻腔、鼻窦的炎症性疾病如过敏性鼻炎、鼻窦炎、原发性纤毛运动障碍和囊性纤维化中的作用。
关键词: 哮喘、炎症、哼唱、PCD、鼻息肉、鼻、鼻窦炎
Current Medicinal Chemistry
Title:Recent Advances on Nitric Oxide in the Upper Airways
Volume: 23 Issue: 24
Author(s): Mauro Maniscalco, Andrea Bianco, Gennaro Mazzarella, Andrea Motta
Affiliation:
关键词: 哮喘、炎症、哼唱、PCD、鼻息肉、鼻、鼻窦炎
摘要: Exhaled nitric oxide (NO) originates from the upper airways, and takes action, to varying extents, in regulation, protection and defense, as well as in noxious processes. Nitric oxide retains important functions in a wide range of physiological and pathophysiological processes of the human body, including vaso-regulation, antimicrobial activity, neurotransmission and respiration. This review article reports the ongoing investigations regarding the source, biology and relevance of NO within upper respiratory tract. In addition, we discuss the role of NO, originating from nasal and paranasal sinuses, in inflammatory disorders such as allergic rhinitis, sinusitis, primary ciliary dyskinesia, and cystic fibrosis.
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Cite this article as:
Mauro Maniscalco, Andrea Bianco, Gennaro Mazzarella, Andrea Motta , Recent Advances on Nitric Oxide in the Upper Airways, Current Medicinal Chemistry 2016; 23 (24) . https://dx.doi.org/10.2174/0929867323666160627115335
DOI https://dx.doi.org/10.2174/0929867323666160627115335 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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