Title:Targeting Apelinergic System in Cardiometabolic Disease
Volume: 18
Issue: 15
Author(s): Rui Guo, Olivia Rogers and Sreejayan Nair*
Affiliation:
- School of Pharmacy, University of Wyoming and the Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071,United States
Keywords:
Apelin, apelinergic receptor, energy metabolism, cardiovascular disease, diabetes, metabolic syndrome, polymorphism.
Abstract: Background: Global burden of cardiometabolic disease warrants development of newer
treatment strategies. Apelin is ubiquitously expressed endogenous peptide which is a ligand for the
apelinergic (APJ) receptor. Apelin/APJ receptors regulate a variety of biological functions and have
been implicated in cardiovascular and metabolic homeostasis. Consequently, the apelinergic pathway
represents an attractive target to treat conditions associated with cardiometabolic syndrome.
Objective: This review highlights the important regulatory role played by apelin in energy metabolism
and cardiovascular function, and potential avenues that could be harnessed for therapeutic benefit.
Conclusion: Apelin/APJ system is a druggable target to treat or prevent a variety of cardiometabolic
diseases.