Title:Current Perspectives on Novel Drug Delivery Systems and Therapies for Management of Prostate Cancer: An Inclusive Review
Volume: 18
Issue: 11
Author(s): Rohit R. Bhosale*, H. V. Gangadharappa, Umme Hani*, Riyaz Ali M. Osmani, Rudra Vaghela, P. K. Kulkarni and Venkata Sairam Koganti
Affiliation:
- Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysuru- 570015, Karnataka,India
- Department of Pharmaceutics, King Khalid University, Abha- 62529,Saudi Arabia
Keywords:
Prostate cancer, delivery systems, brachytherapy, orchiectomy, gene therapy, drug targets.
Abstract: Background: Prostate cancer (PC) is a prostate gland cells carcinoma, the foremost reason
of cancer deaths in men in developed countries, representing most common malignancy in adult
males. The key obstacle to achieve practicable therapeutic effect of active drugs and capable hopeful
agents including proteins and peptides, and nucleic acid for prostate cancer is the scarcity of targeted
drug delivery to cells of prostate cancer. As a result, need for novel systems, strategies or therapeutic
approaches to enhance the assortment of active agents meant for prostate cancer becomes an important
criterion. Currently cancer research focuses on improving treatment of prostate cancer using
various novel drug delivery systems of chemotherapeutic agents. These novel drug delivery systems
comprise nanoparticles and liposomes. Also, strategies or therapeutic approaches intended for the
prostate cancer include radiation therapy for localized prostate cancer, hormonal therapy for suppressing
tumor growth, and gene-and-immunologic therapy. These systems and approaches can deliver
the drugs to their selected or targeted cancer cells for the drug release in cancer atmosphere of
prostate thereby enhancing the effectiveness of tumor penetration.
Objective: The objective was to collect and report the recent research findings to manage the PC.
Present review encloses existing diverse novel drug delivery systems and approaches intended for the
management of PC.
Conclusion: The reported miscellaneous novel drug delivery systems along with the diverse therapies
are seem to be precise, secure and relatively effective; and in consequence could lead to a new
track for obliteration of prostate cancer.
