Title:Recent Advances in Anti-inflammatory Potential of Pyridazinone Derivatives
Volume: 16
Issue: 12
Author(s): Minaxi Saini, Dinesh Kumar Mehta, Rina Das and Gurnam Saini
Affiliation:
Keywords:
Anti-inflammatory, Cyclooxygenase inhibitors, Inflammation, Pyridazinone.
Abstract: Pyridazinone and its derivatives have various ranges of biological and pharmacological
activities including anti-inflammatory, antifeedant, anticonvulsant, antidiabetic, herbicidal,
antihypertensive, antiplatelet, antifungal, antibacterial, anticancer and antiviral activities. Pyridazinone
magic moiety has allowed the generation of a huge number of structurally different derivatives. Most
of the pyridazinone derivatives are derived from substitution of the pyridazinone oxygen, nitrogen and
C4/C5/C6 carbon positions. Pyridazinone can be used for the synthesis of a large variety of
heterocyclic compounds and as intermediate for a broad spectrum of drug synthesis. Constant use of
non-steroidal anti-inflammatory drugs is often accompanied by side effects such as bleeding, nephrotoxicity and
gastrointestinal lesions. To minimise these side effects some of the pyridazinone derivatives are synthesised with an
improved gastrointestinal tract and renal safety profile linked to other non-steroidal anti-inflammatory drugs. In this
review, we have discussed the pyridazinone nucleus which serves as an important therapeutic agent in the field of nonsteroidal
anti-inflammatory drugs. This nucleus has a wide spectrum in bioorganic and medicinal chemistry and
application in drug discovery.
