摘要
结核分枝杆菌(M. tuberculosis),几乎是一个基因独占的病原一种人体寄生虫,传播主要通过人类和引起结核病(TB)。虽然缺乏适当的营养,降低免疫状态是疾病发展的因素,但结核病与贫穷密切相关。结核病仍然是仅次于艾滋病毒/艾滋病的引领全球死亡率的病,主要原因是由于一个单一的传染性病原体,每年导致近150万人死亡。这里我们总结了关于结核分枝杆菌肺结核的生理学和它与人类的相互作用的一些步骤知识的发展。这一进展为提高结核感染的诊断和治疗提供了充分的空间。在高负担的国家的结核病诊断实验室里结核分枝杆菌药敏试验(DST)前第一步是进行初步分离。对肺结核的诊断基于IGRA(干扰素-γ释放法)的测试是足够快的,具体的和允许含有感染和区分那些在接受抗结核治疗后有临床抗结核治疗后结核感染和卡介苗接种疫苗的人。
关键词: 结核分枝杆菌,结核,结核的诊断,IGRA(干扰素-γ释法),药敏试验(DST),多药耐药(MDR)结核、维生素D、一氧化氮(NO)、促炎和抗炎细胞因子,过渡金属
Current Medicinal Chemistry
Title:Human Tuberculosis I. Epidemiology, Diagnosis and Pathogenetic Mechanisms
Volume: 23 Issue: 25
Author(s): Giampietro Sgaragli and Maria Frosini
Affiliation:
关键词: 结核分枝杆菌,结核,结核的诊断,IGRA(干扰素-γ释法),药敏试验(DST),多药耐药(MDR)结核、维生素D、一氧化氮(NO)、促炎和抗炎细胞因子,过渡金属
摘要: Mycobacterium tuberculosis (M. tuberculosis), an almost genetically monomorphic pathogen is a human parasite, transmitted mostly by humans and causes tuberculosis (TB). TB is firmly associated to poverty, although lack of proper nutrition and lowered immune status are contributing factors for disease development. TB remains second only to HIV/AIDS as the leading cause of mortality worldwide due to a single infectious agent and is responsible for nearly 1.5 million deaths annually. Some steps of the progress of our knowledge of M. tuberculosis physiology and its interactions with human beings, are reviewed here. This progress has provided fertile ground for improving diagnosis and cure of TB infection. For TB diagnostics laboratories in high-burden countries, primary isolation is the first step before performing drug susceptibility testing (DST) of M. tuberculosis. IGRA (interferon-γ release assay)-based tests for diagnosis of active TB are sufficiently fast, specific and sensitive to allow to contain infection and distinguish among latent TB infection and BCG vaccination individuals from those who have clinically resolved M. tuberculosis infection after anti-TB treatment.
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Cite this article as:
Giampietro Sgaragli and Maria Frosini , Human Tuberculosis I. Epidemiology, Diagnosis and Pathogenetic Mechanisms, Current Medicinal Chemistry 2016; 23 (25) . https://dx.doi.org/10.2174/0929867323666160607222854
DOI https://dx.doi.org/10.2174/0929867323666160607222854 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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