Title:Neurodegeneration with Dementia: From Fundamentals of Pathology to Clinical Imaging by MRI and SPECT.
Volume: 12
Author(s): Michael Cordes, Zbigniew Wszolek, Wolfgang Bruck, Anna Zimny, Marek Sasiadek and Torsten Kuwert
Affiliation:
Keywords:
Alzheimer's disease, frontotemporal lobe dementia, Lewy body dementia, MRI, SPECT, neurodegenerative disorders
with dementia.
Abstract: The increasing incidence of neurodegenerative disorders with dementia
(NDD) requires structural and functional imaging methods which are easily available
in the clinical setting. The diagnostic work-up for patients who have NDD includes
magnetic resonance imaging (MRI), single-photon emission computed tomography
(SPECT), and positron emission tomography (PET). Both, MRI and
SPECT can show characteristic findings of NDD. However, the interpretation of
these findings has to be done in the context of clinical data, which includes biochemical
and histological examinations. In this article, we review recent advances
in pathology and the impact of these advances on MRI and SPECT studies interpretations.
We present a literature review describing typical MRI and SPECT findings
and the diagnostic accuracies reported for NDD. Combining MRI and SPECT examinations
with quantitative evaluation of clinical data further improves the diagnostic potential of these imaging
procedures for NDD.
