Title:Imidazo[1,2-a]pyridine Scaffold as Prospective Therapeutic Agents
Volume: 17
Issue: 2
Author(s): Aakash Deep, Richa Kaur Bhatia, Ramanjot Kaur, Sanjiv Kumar, Upendra Kumar Jain, Harinder Singh, Sandeep Batra, Dinesh Kaushik and Pran Kishore Deb
Affiliation:
Keywords:
Imidazo[1, 2-a]pyridines, Antimicrobial, Anticancer, Anticonvulsant, Antiviral.
Abstract: Imidazo[1,2-a]pyridine is one of the most potential bicyclic 5–6 heterocyclic rings that is
recognized as a “drug prejudice” scaffold due to its broad range of applications in medicinal chemistry
such as anticancer, antimycobacterial, antileishmanial, anticonvulsant, antimicrobial, antiviral, antidiabetic,
proton pump inhibitor, insecticidal activities. This scaffold has also been represented in
various marketed preparations such as zolimidine, zolpidem, alpidem. Therefore, several attempts
were made to carry out the structural modifications of this scaffold to discover and develop novel
therapeutic agents. This review provides a valuable insight into the research findings of wide range of
derivatives of imidazo[1,2-a]pyridine scaffold leading to promising heterocyclic compounds which
could be explored further for the synthesis of new derivatives as well as construction of potential
drug-like chemical libraries for biological screening in search of new therapeutic agents.
