摘要
将人类免疫缺陷病毒(HIV)感染者与同年龄的健康人进行比较,人类免疫缺陷病毒(HIV)感染者有更高的患病感染率。复杂的艾滋病毒引起的免疫抑制,慢性抗原刺激,以及致癌病毒共同感染之间的关系,可能会促进肿瘤的发生,并增加这些患者肿瘤发展的风险。艾滋病感染者的癌症包括艾滋病定义恶性肿瘤(ADMS)和其他非艾滋病定义恶性肿瘤(NADMs)。抗逆转录病毒疗法减少了ADMs 的发病率,在过去几年中观察到,同时增加了NADMs的发生率。生物标志物是可测量的参数,表征了正常或致病的过程,它具有高潜能去进行患者的风险评估和诊断。因此,艾滋病毒阳性患者的癌症生物标志物早期检测将十分有用以确定患者在大多数肿瘤疾病发展中的风险。本次审查将重点集中于艾滋病的恶性肿瘤生物标志物上,细胞和病毒生物标志物,包括细胞因子,免疫激活分子和遗传多态性的几个生物标志物的风险评估和诊断的作用。
关键词: 艾滋病恶性肿瘤;肿瘤标志物;癌症艾滋病病毒;霍奇金淋巴瘤;非艾滋病恶性肿瘤;非霍奇金淋巴瘤。
Current Medicinal Chemistry
Title:The Role of Cancer Biomarkers in HIV Infected Hosts
Volume: 23 Issue: 22
Author(s): Domenico Galati, Serena Zanotta
Affiliation:
关键词: 艾滋病恶性肿瘤;肿瘤标志物;癌症艾滋病病毒;霍奇金淋巴瘤;非艾滋病恶性肿瘤;非霍奇金淋巴瘤。
摘要: A higher incidence of cancer has been observed in Human Immunodeficiency Virus (HIV) infected individuals as compared with healthy people of the same age. A complex relationship between HIV-induced immune suppression, chronic antigenic stimulation, and oncogenic virus co-infections may promote carcinogenesis and increase the risk of developing tumors in these patients. Cancers in HIV subjects include the AIDS-defining malignancies (ADMs) and other non-AIDS-defining malignancies (NADMs). Antiretroviral therapy has reduced the incidence of ADMs whereas a concurrent increase of NADMs was observed in the last years. Biomarkers are measurable parameters, characterizing normal or pathogenic processes, which could provide a high potential for risk evaluation and diagnosis of patients. Therefore, the early detection of cancer biomarkers in HIV-positive subjects would be useful to identify patients at most risk of tumor disease development.
This review will focus principally on the risk assessment and diagnostic role of several biomarkers of malignancy in HIV patients including cellular and viral biomarkers, cytokines, immune activation molecules and genetic polymorphisms.
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Cite this article as:
Domenico Galati, Serena Zanotta , The Role of Cancer Biomarkers in HIV Infected Hosts, Current Medicinal Chemistry 2016; 23 (22) . https://dx.doi.org/10.2174/0929867323666160530145102
DOI https://dx.doi.org/10.2174/0929867323666160530145102 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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