摘要
多酚在植物界天然产物中构成至关重要的一部分,目前已知的大约有8000个酚类化合物。水果,蔬菜,全谷物和其他几种食品和饮料(例如茶,巧克力和葡萄酒)是多酚的重要来源。科学文献提供了临床前实验证据关于在植物提取物中发现的多酚化合物在神经性疼痛的动物模型中的镇痛作用的。不仅神经性疼痛被减弱:实际上,由刺激神经纤维(体细胞或内脏)引起的伤害性疼痛仅响应接近或超过有害强度阈值(伤害感受器)的刺激,以及与炎性疼痛相关组织损伤和免疫细胞的浸润,都被多酚减少和减轻。本文是综述多酚的镇痛效果。
关键词: 疼痛
Current Drug Targets
Title:New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain
Volume: 18 Issue: 2
关键词: 疼痛
摘要: Polyphenols constitute a group of a paramount importance within the natural products in the plant kingdom, with an approximate amount of 8000 phenolic structures currently known. Fruits, vegetables, whole grains and several other foods and beverages (as tea, chocolate and wine, for instance) are rich and important sources of polyphenols. The scientific literature provides pre-clinical experimental evidence on the antinociceptive effects of polyphenolic compounds, found in plant extracts, in animal models of neuropathic pain. But not only neuropathic pain is attenuated: in fact, nociceptive pain, caused by stimulation of nerve fibers (either somatic or visceral) responding only to stimuli approaching or exceeding harmful intensity thresholds (nociceptors), and also inflammatory pain, which is associated with tissue damage and infiltration of immune cells, are both reduced and alleviated by polyphenols. In the present work, the antinociceptive effects of polyphenols are reviewed.
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New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain, Current Drug Targets 2017; 18 (2) . https://dx.doi.org/10.2174/1389450117666160527142423
DOI https://dx.doi.org/10.2174/1389450117666160527142423 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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