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摘要
小细胞肺癌是一种侵袭性强、难治疗的肿瘤。在所有肺肿瘤中,小细胞肺癌约占20%。患者通常包括70岁年龄组的重度吸烟者,诊疗期间有如下症状,如胸腔内肿瘤生长症状,远处播散或副肿瘤综合征。一个有用的和功能的分类将小细胞肺癌分为局限性疾病和广泛性疾病。同期化疗是限制性疾病的标准治疗方法,与预防性头颅照射联合使用可提高生存率。铂类药物(顺铂/卡铂加依托泊苷)是广泛的疾病的基石。然而,尽管这种癌症的化疗和辐射敏感性高,几乎所有患者在最初两年内复发,预后极差。一个更深入的了解小细胞肺癌的发生发展和测试了相当数量的新的和有针对性的药物,但目前的结果是弱或不足。迄今为止,小细胞肺癌仍然是研究人员面临的挑战。在这篇综述中,就小细胞肺癌的管理和标准和新的治疗方法的争议点的关键方面进行讨论。
关键词: 化疗,免疫治疗,管理,放射治疗,小细胞肺癌,靶向治疗。
Current Drug Targets
Title:Small-Cell Lung Cancer: Clinical Management and Unmet Needs New Perspectives for an Old Problem
Volume: 18 Issue: 3
Author(s): Giuseppe Lo Russo, Marianna Macerelli, Marco Platania, Nicoletta Zilembo, Milena Vitali, Diego Signorelli, Claudia Proto and Monica Ganzinelli, Rosaria Gallucci, Francesco Agustoni, Gianpiero Fasola, Filippo de Braud, Marina Chiara Garassino.
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关键词: 化疗,免疫治疗,管理,放射治疗,小细胞肺癌,靶向治疗。
摘要: Small cell lung cancer is a highly aggressive, difficult to treat neoplasm. Among all lung tumors, small cell lung cancers account for about 20%. Patients typically include heavy smokers in 70s age group, presenting with symptoms such as intrathoracic tumors growth, distant spread or paraneoplastic syndromes at the time of diagnosis. A useful and functional classification divides small cell lung cancers into limited disease and extensive disease. Concurrent chemo-radiotherapy is the standard treatment for limited disease, with improved survival when combined with prophylactic cranial irradiation. Platinum compounds (cisplatin/carboplatin) plus etoposide remain the cornerstone for extensive disease. Nevertheless, despite high chemo- and radio-sensitivity of this cancer, nearly all patients relapse within the first two years and the prognosis is extremely poor. A deeper understanding about small cell lung cancer carcinogenesis led to develop and test a considerable number of new and targeted agents but the results are currently weak or insufficient. To date, small cell lung cancer is still a challenge for researchers. In this review, key aspects of small cell lung cancer management and controversial points of standard and new treatments will be discussed.
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Giuseppe Lo Russo, Marianna Macerelli, Marco Platania, Nicoletta Zilembo, Milena Vitali, Diego Signorelli, Claudia Proto and Monica Ganzinelli, Rosaria Gallucci, Francesco Agustoni, Gianpiero Fasola, Filippo de Braud, Marina Chiara Garassino. , Small-Cell Lung Cancer: Clinical Management and Unmet Needs New Perspectives for an Old Problem, Current Drug Targets 2017; 18 (3) . https://dx.doi.org/10.2174/1389450117666160502152331
DOI https://dx.doi.org/10.2174/1389450117666160502152331 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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