Title:The Roles of Sox Family Genes in Sarcoma
Volume: 17
Issue: 15
Author(s): Jingyuan Li, Jacson Shen, Kunzheng Wang, Francis Hornicek and Zhenfeng Duan
Affiliation:
Keywords:
Sox family genes, sarcoma, pagthogenesis, targeted therapy.
Abstract: Sox (SRY-related HMG-box) family genes are important regulators of cell
development, homeostasis, and regeneration. Deregulation of certain members of the
Sox gene family has been implicated in a number of human malignancies, including in
sarcoma. Accumulating evidence suggests that Sox genes play crucial roles in sarcoma
cell pathogenesis, growth, and proliferation. Here, we review the biological
relevance of Sox2 and Sox9 genes in osteosarcoma, chondrosarcoma and chordoma;
Sox2, Sox6, and Sox17 genes in Ewing’s sarcoma; Sox2, Sox9, and Sox10 genes in
synovial sarcoma; Sox2 gene in fibrosarcoma; and Sox21 gene in liposarcoma. These
findings potentiate the targeting of Sox genes for novel therapeutic interventions in
sarcoma and may also hold valuable clinical potential to improve the care of patients
with sarcoma.
