摘要
炎症会产生一种针对细菌、病毒和其他病原体感染或感染的全身反应。宿主福利是这个过程的主要目标。然而,不受控制的或不足的调节炎症反应产生不利影响,导致各种慢性疾病的发生,包括动脉粥样硬化、糖尿病、神经退行性疾病,癌症和伴随严重的组织损伤的阿尔茨海默氏病。炎症刺激的确切身份仍然是难以捉摸的,因为它们在多个途径的功能,因此针对特定的途径不解决问题。现有的靶向治疗炎症反应包括甾体类抗炎药(SAIDs)和非甾体类抗炎药(NSAIDs)。尽管其有众多的有益效果,但甾体类抗炎药以及非甾体类抗炎药都有其独立的、不可避免的副作用,导致长期治疗中的应用。由于不受控制的炎症的管理对总体幸福感是至关重要的,因此,多目标的替代来源的多靶向性无毒治疗干预是强制性的。植物衍生的酚类构成这样一组分子,可以用来管理炎症。他们的协同调节参与多种信号通路调节失控的炎症表现出有益健康的效果的几个重要组成部分。本文综述了一些抗炎多酚结构功能活动的最新进展,其生物利用度提高,临床/临床前研究结果提供了遵循以最小的副作用的促炎反应系统生物学发展的新型抗炎药物的知识。
关键词: 生物制剂,剂型,脂质体,胶束,纳米颗粒,药,白藜芦醇,槲皮素、姜黄素。
Current Medicinal Chemistry
Title:Management of Inflammation by Natural Polyphenols: A Comprehensive Mechanistic Update
Volume: 23 Issue: 16
Author(s): Souvik Sarkar, Somnath Mazumder, Shubhra J. Saha, Uday Bandyopadhyay
Affiliation:
关键词: 生物制剂,剂型,脂质体,胶束,纳米颗粒,药,白藜芦醇,槲皮素、姜黄素。
摘要: Inflammation generates a systemic response against injury or infection from bacteria, viruses, and other pathogens. The welfare of host is the primary target of this process. However, uncontrolled or inadequate regulation of the inflammatory response produces detrimental effects leading to the generation of various chronic disorders including atherosclerosis, type-2 diabetes, neurodegenerative disease, cancer and Alzheimer’s disease with severe tissue damage. The exact identity of the inflammatory stimuli is still elusive as they function in multiple pathways; therefore targeting a particular pathway does not resolve the problem. Existing therapeutics targeting the inflammatory responses include steroidal antiinflammatory drugs (SAIDs) and nonsteroidal antiinflammatory drugs (NSAIDs). In spite of their numerous beneficial effects, both SAIDs as well as NSAIDs have their independent, unavoidable side effects, which discourage their prolonged therapeutic applications. Since the management of uncontrolled inflammation is critical for the general wellbeing, therefore an alternative source of multi-targeted non-toxic therapeutic intervention is mandatory. Plant-derived phenols constitute such a group of molecules that can be utilised to manage inflammation. They synergistically modulate several important components involved in multiple signalling pathways that regulate uncontrolled inflammation to exhibit their beneficial health effects. This review discusses the recent advances in structure-function activity of some antiinflammatory polyphenols, their bioavailability enhancement, clinical/ preclinical findings with a view to provide knowledge for developing novel antiinflammatory drugs by following system biology of proinflammatory responses with minimal side effects.
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Souvik Sarkar, Somnath Mazumder, Shubhra J. Saha, Uday Bandyopadhyay , Management of Inflammation by Natural Polyphenols: A Comprehensive Mechanistic Update, Current Medicinal Chemistry 2016; 23 (16) . https://dx.doi.org/10.2174/0929867323666160418115540
DOI https://dx.doi.org/10.2174/0929867323666160418115540 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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