烟酸对急性高脂血症的药理作用

Title:Pharmacological Effects of Niacin on Acute Hyperlipemia

Volume: 23 Issue: 25

Author(s): Sergio Montserrat-de la Paz, Beatriz Bermudez, M. Carmen Naranjo, Sergio Lopez, Rocio Abia, Francisco J.G. Muriana

Affiliation:

关键词: 烟酸，维生素B3，高脂血症，富含甘油三酯的脂蛋白，餐后状态，心血管疾病。

摘要: The well-known changes in modern lifestyle habits including over nutrition and physical inactivity have led to striking adverse effects on public health (e.g., obesity, diabetes, and metabolic syndrome) over recent decades. One noticeable consequence is exaggerated and prolonged state of postprandial hyperlipemia due to the ingestion of multiple fat-enriched meals during the course of a day. Postprandial (non-fasting) hyperlipemia is characterized by increased blood levels of exogenous triglycerides (TG) in the form of apolipoprotein (apo) B48-containing TG-rich lipoproteins (TRL), which have a causal role in the pathogenesis and progression of cardiovascular disease (CVD). The cardiovascular benefits of lifestyle modification (healthy diet and exercise) and conventional lipid-lowering therapies (e.g., statins, fibrates, and niacin) could involve their favourable effects on postprandial metabolism. Pharmacologically, niacin has been used as an athero-protective drug for five decades. Studies have since shown that niacin may decrease fasting levels of plasma verylow- density lipoproteins (VLDL), low-density lipoprotein cholesterol (LDL-C), and lipoprotein [a] (Lp[a]), while may increase high-density lipoprotein cholesterol (HDL-C). Herein, the purpose of this review was to provide an update on effects and mechanisms related to the pharmacological actions of niacin on acute hyperlipemia.

Cite this article as:

Sergio Montserrat-de la Paz, Beatriz Bermudez, M. Carmen Naranjo, Sergio Lopez, Rocio Abia, Francisco J.G. Muriana , Pharmacological Effects of Niacin on Acute Hyperlipemia, Current Medicinal Chemistry 2016; 23 (25) . https://dx.doi.org/10.2174/0929867323666160411142909