Title:Hybolites Revisited
Volume: 11
Issue: 1
Author(s): Victor Norris, Cecile Verrier and Marc Feuilloley
Affiliation:
Keywords:
Antibiotic, cancer, infection, macromolecular assembly, pathogen, polyphosphate.
Abstract: Background: Hyperstructures are large assemblies of molecules and macromolecules
that perform functions such as metabolism (including RNA and protein synthesis
and degradation), transport, DNA replication, cell division, signalling and chemotaxis.
Methods: Such hyperstructures might be manipulated by hybrid metabolites or hybolites
made by a pairwise, covalently linked combination of the thousands of small molecules involved
in metabolism and signalling.
Results: Here, we review recent evidence for hyperstructures in prokaryotes and for interactions between hyperstructures
as a determinant of the phenotype.
We also mention extending hybolite therapy to eukaryotes, consider new designs for hybolites, and discuss
relevant patents.
