Title:Pediatric Lupus Nephritis-Review of Literature
Volume: 13
Issue: 1
Author(s): Neha Thakur, Narendra Rai and Prerna Batra
Affiliation:
Keywords:
Advancements, cyclophosphamide, lupus nephritis, mofetil, mycophenolate, pediatric.
Abstract: Systemic lupus erythematous (SLE) is a multisystem autoimmune disorder characterized
by immune dysregulation and formation of autoantibodies. A high index of suspicion is necessary to
diagnose SLE. Children have more systemic involvement than adults. Kidney involvement is seen in
a significant proportion of children. With advancement of therapy the survival rate of patients with
SLE has significantly improved. Even then lupus nephritis is still the most important predictor of
morbidity and mortality. Treatment of lupus nephritis is mostly derived from studies in adults as data
on children is still lacking. Prednisolone and cyclophosphamide was the mainstay of treatment till
now. Recently drugs like mycophenolate mofetil, azathioprine, rituximab are also being used in
treatment of lupus nephritis with promising results and without significant adverse effects.
In this review we will be discussing lupus nephritis, its diagnosis, pathogenesis, clinical picture and
treatment advancements.