Title:Modelling Chemotherapy-induced Cardiotoxicity by Human Pluripotent Stem Cells
Volume: 18
Issue: 6
Author(s): Rosalinda Madonna*, Christian Cadeddu, Martino Deidda, Paolo Spallarossa, Concetta Zito and Giuseppe Mercuro*
Affiliation:
- Dipartimento di Scienze Mediche Mario Aresu, Universita of Cagliari,Italy
- Department of Medical Sciences “Mario Aresu”, University of Cagliari, Cagliari,Italy
Keywords:
Cardiac stem cells, chemotherapy-induced cardiotoxicity, pluripotent stem cells, preclinical models, cardiomyopathy,
human embryomic stem cell.
Abstract: Novel antineoplastic therapies have greatly improved cancer survival; nevertheless they are
bringing in new forms of cardiomyopathy, that can often limit proper cancer treatments. Novel cardioprotective
therapies are therefore needed, for improving clinical outcomes in cancer patients. In order to
test novel therapeutic strategies, there is an increasing need for appropriate experimental models of
chemotherapy-induced cardiomyopathy. Induced pluripotent stem (iPS) cell- and human embryonic
stem cell (hESC )-derived cardiomyocytes may be used as alternative in vitro models for studying
mechanisms that underly chemotherapy-induced cardiomyopathy. In this review we discuss the use of
iPS- and hESC-derived cardiomyocytes for evaluating additional pharmacological targets and for predicting
chemotherapy-induced cardiotoxicity.
