摘要
植物细胞代谢物是从植物衍生的功能元件,其中大多数表现出抗癌,抗炎和抗氧化作用等治疗特征。 Phytometabolites通过靶向多种信号通路发挥其抗癌作用。植物代谢物靶向的显着现象之一是Warburg效应。 Warburg效应描述了与正常细胞相比,癌细胞表现出增加的糖酵解速率和异常氧化还原活性的观察。这种现象促进癌症的进一步发展和进步。最近的观察显示,一些植物代谢物可以靶向癌细胞中的代谢相关酶(例如己糖激酶,丙酮酸激酶M2,HIF-1),对正常细胞几乎没有或没有损害。由于癌细胞的高增殖是通过较高的细胞代谢来驱动的,针对这些代谢途径的植物代谢产物可以产生与诱导的凋亡途径的协同串扰并使癌细胞对化学治疗剂敏感。在这篇综述中,我们讨论了针对Warburg效应的植物代谢产物和导致肿瘤生长抑制的潜在分子机制。
关键词: 癌症,糖酵解,氧化磷酸化,植物代谢物,氧化还原活性,Warburg效应
Current Drug Targets
Title:Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic Review
Volume: 18 Issue: 9
关键词: 癌症,糖酵解,氧化磷酸化,植物代谢物,氧化还原活性,Warburg效应
摘要: Phytometabolites are functional elements derived from plants and most of them exhibit therapeutic characteristics such as anti-cancer, anti-inflammatory and anti-oxidant effects. Phytometabolites exert their anti-cancer effect by targeting multiple signaling pathways. One of the remarkable phenomena targeted by phytometabolites is the Warburg effect. The Warburg effect describes the observation that cancer cells exhibit an increased rate of glycolysis and aberrant redox activity compared to normal cells. This phenomenon promotes further cancer development and progression. Recent observations revealed that some phytometabolites could target metabolic-related enzymes (e.g. Hexokinase, Pyruvate kinase M2, HIF-1) in cancer cells, with little or no harm to normal cells. Since hyper-proliferation of cancer cells is fueled by higher cellular metabolism, phytometabolites targeting these metabolic pathways can create synergistic crosstalk with induced apoptotic pathways and sensitize cancer cells to chemotherapeutic agents. In this review, we discuss phytometabolites that target the Warburg effect and the underlying molecular mechanism that leads to tumor growth suppression.
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Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic Review, Current Drug Targets 2017; 18 (9) . https://dx.doi.org/10.2174/1389450117666160401124842
DOI https://dx.doi.org/10.2174/1389450117666160401124842 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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