摘要
花生四烯酸代谢酶,环氧合酶-2(COX-2)和5-脂氧合酶(5-LOX),在结肠的癌变过程均高表达。在腺瘤形成早期阶段吸烟促进这些致癌过程。在这篇文章中,对环氧合酶-2和5-脂氧合酶的参与,与双重环氧合酶/5-脂氧合酶抑制剂在结肠直肠癌的发展做了介绍。本文也描述了在结肠癌的生长中5-脂氧合酶和环氧合酶-2共同管制以及它们与香烟烟雾、透明质酸-cd44v6的关系。按照设想,5-脂氧合酶 /环氧合酶双重抑制可能是在人类结直肠癌治疗中最有前景的治疗选择。
关键词: 5 -脂氧合酶,环氧合酶 - 2,香烟烟雾,结肠癌,lincofelone,透明质酸。
Current Medicinal Chemistry
Title:The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons
Volume: 23 Issue: 11
Author(s): J. Shen, W.X. Li, Z.G. Xiao, L. Zhang, M.X. Li, L.F. Li, W. Hu, L. Lu, F. Boudreau, C.H. Cho
Affiliation:
关键词: 5 -脂氧合酶,环氧合酶 - 2,香烟烟雾,结肠癌,lincofelone,透明质酸。
摘要: The arachidonic acid metabolizing enzymes, cyclooxygenase-2 (COX-2) and 5- lipoxygenase (5-LOX), are both highly expressed during the carcinogenesis in colons. Cigarette smoking promotes these carcinogenic processes at the early stage during adenoma formation. In this article, the involvement of COX-2 and 5-LOX, alongside with the dual COX/5-LOX inhibitors in colorectal cancer development is introduced. The co-regulation of 5-LOX and COX-2 in colon cancer growth and its relationship with cigarette smoke and hyaluronic acid-CD44v6 is also described. It is envisaged that dual inhibition of 5-LOX/COX could be the most promising therapeutic option for the treatment of colorectal cancer in humans.
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J. Shen, W.X. Li, Z.G. Xiao, L. Zhang, M.X. Li, L.F. Li, W. Hu, L. Lu, F. Boudreau, C.H. Cho , The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons, Current Medicinal Chemistry 2016; 23 (11) . https://dx.doi.org/10.2174/0929867323666160321122431
DOI https://dx.doi.org/10.2174/0929867323666160321122431 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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