在中枢神经系统中一氧化氮是假设为雅努斯之脸？

Title:Is Nitric Oxide Assuming a Janus-Face in The Central Nervous System?

Volume: 23 Issue: 16

Author(s): Felicity Ockelford, Louis Saada, Ehud Gazit, Achala de Mel

Affiliation:

关键词: 一氧化氮，神经退行性疾病，神经保护，阿尔茨海默氏症，帕金森氏症。

摘要: Nitric Oxide, synthesized from L-arginine by the nitric oxide synthases, has a complex role within the human body. It contributes to almost every physiological system and has been found to be both protective and toxic in disease states. An aging population faces an increasing incidence of neurodegenerative disease and the pathological action of nitric oxide in Alzheimer’s and Parkinson’s diseases may be important therapeutic targets for the future. Nitric oxide’s protective effects are also important to consider, through inhibition of caspase-3, nitrosylation of NMDA and increased activation of protein kinase B and CREB transcription factor. Nitric oxide has been shown to play a part in long term potentiation, revealing its importance in synaptic plasticity. Due to nitric oxide’s mixed effects it is an exciting and varied therapeutic target. Currently, the impact of these therapies has been explored and developed in animal studies, but is yet to be fully realized in human trials. This paper outlines both the pathological and protective roles of nitric oxide in the central nervous system and the potential pharmacological therapies and targets these indicate.

Cite this article as:

Felicity Ockelford, Louis Saada, Ehud Gazit, Achala de Mel , Is Nitric Oxide Assuming a Janus-Face in The Central Nervous System?, Current Medicinal Chemistry 2016; 23 (16) . https://dx.doi.org/10.2174/0929867323666160316124137