锂的治疗和亚治疗剂量明显地调节神经元和神经胶质细胞共培养的炎前和抗炎性白细胞介素的分泌

Title:Lithium Distinctly Modulates the Secretion of Pro- and Anti- Inflammatory Interleukins in Co-Cultures of Neurons and Glial Cells at Therapeutic and Sub-Therapeutic Concentrations

Volume: 13 Issue: 8

Author(s): Vanessa J. De-Paula, Daniel S. Kerr, Gustavo Scola, Wagner F. Gattaz, Orestes V. Forlenza

Affiliation:

关键词: 共培养，皮层神经元，海马神经元，锂，神经保护作用，炎前和抗炎的白细胞介素。

摘要: Lithium is associated with various effects on immune functions, some of which are still poorly understood. The roles of many cytokines have been characterized in a variety of neurodevelopmental processes including neurogenesis, neuronal and glial cell migration, proliferation, differentiation, synaptic maturation and synaptic pruning. This work aims to evaluate the effects of different doses of lithium (0.02; 0.2 and 2mM) on the secretion of cytokines in co-cultures of cortical and hippocampal neurons with glial cells. Our results indicate that chronic treatment with lithium chloride at subtherapeutic concentrations are able to modify the secretion of pro- and anti-inflammatory interleukins in co-cultures of cortical and hippocampal neurons with glial cells.

Cite this article as:

Vanessa J. De-Paula, Daniel S. Kerr, Gustavo Scola, Wagner F. Gattaz, Orestes V. Forlenza , Lithium Distinctly Modulates the Secretion of Pro- and Anti- Inflammatory Interleukins in Co-Cultures of Neurons and Glial Cells at Therapeutic and Sub-Therapeutic Concentrations, Current Alzheimer Research 2016; 13 (8) . https://dx.doi.org/10.2174/1567205013666160219112612