Title:Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?
Volume: 16
Issue: 27
Author(s): Elina Buitrago, Renaud Hardré, Romain Haudecoeur, Hélène Jamet, Catherine Belle, Ahcène Boumendjel, Luigi Bubacco and Marius Réglier
Affiliation:
Keywords:
Melanoma, Tyrosinase, TRP-1, TRP-2, Tyrosinase effectors.
Abstract: Among the human copper-containing monooxygenases, Tyrosinase (Ty)
is an important enzyme involved in the determinant step of the biosynthetic pathway
of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation
into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin
production, so their development has a huge economical and industrial impact.
Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches,
due to the complex biochemical reaction involved in the melanin synthesis.
