摘要
动物毒液是具有生物活性的混合物,作为一种武器,它主要被用于固定和杀死猎物。由于高效价性和特异性,以及生理指标的特异性,很多动物毒液毒素已成为治疗各种疾病的潜在药物,其中包括心血管疾病。卡托普利,,是第一个以毒液为基础成功的药物,它能抑制血管紧张素转化酶(ACE),这是合理的药物设计的显著例子。由于卡托普利发展,许多研究已经发现了对心血管系统的有显著作用的新型缓激肽增强肽(BPPs)。利钠肽(NPS)在动物毒也被发现并被作为设计应用于心血管疾病新药物的模板。抗心律失常肽中,GsmTx-4能选择性抑制牵张激活的阳离子通道(SACS),这与心房颤动有关。本综述讨论了分离于对心血管系统有作用的动物毒液的主要成分并对动物毒液和其参数进行了概括。
关键词: 抗心律失常,缓激肽增强肽、卡托普利、心脑血管、降压、利尿钠肽、蝎子、蛇、蜘蛛、毒、蛇毒。
Current Medicinal Chemistry
Title:Cardiovascular-Active Venom Toxins: An Overview
Volume: 23 Issue: 6
Author(s): Carolina Campolina Rebello Horta, Maria Chatzaki, Bruno Almeida Rezende, Bárbara de Freitas Magalhães, Clara Guerra Duarte, Liza Figueiredo Felicori, Bárbara Bruna Ribeiro Oliveira-Mendes, Anderson Oliveira do Carmo, Carlos Chávez-Olórtegui and Evanguedes Kalapothakis
Affiliation:
关键词: 抗心律失常,缓激肽增强肽、卡托普利、心脑血管、降压、利尿钠肽、蝎子、蛇、蜘蛛、毒、蛇毒。
摘要: Animal venoms are a mixture of bioactive compounds produced as weapons and used primarily to immobilize and kill preys. As a result of the high potency and specificity for various physiological targets, many toxins from animal venoms have emerged as possible drugs for the medication of diverse disorders, including cardiovascular diseases. Captopril, which inhibits the angiotensinconverting enzyme (ACE), was the first successful venom-based drug and a notable example of rational drug design. Since captopril was developed, many studies have discovered novel bradykinin-potentiating peptides (BPPs) with actions on the cardiovascular system. Natriuretic peptides (NPs) have also been found in animal venoms and used as template to design new drugs with applications in cardiovascular diseases. Among the anti-arrhythmic peptides, GsMTx-4 was discovered to be a toxin that selectively inhibits the stretch-activated cation channels (SACs), which are involved in atrial fibrillation. The present review describes the main components isolated from animal venoms that act on the cardiovascular system and presents a brief summary of venomous animals and their venom apparatuses.
Export Options
About this article
Cite this article as:
Carolina Campolina Rebello Horta, Maria Chatzaki, Bruno Almeida Rezende, Bárbara de Freitas Magalhães, Clara Guerra Duarte , Liza Figueiredo Felicori, Bárbara Bruna Ribeiro Oliveira-Mendes, Anderson Oliveira do Carmo, Carlos Chávez-Olórtegui and Evanguedes Kalapothakis , Cardiovascular-Active Venom Toxins: An Overview, Current Medicinal Chemistry 2016; 23 (6) . https://dx.doi.org/10.2174/0929867323666160126142837
DOI https://dx.doi.org/10.2174/0929867323666160126142837 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Diabetes and the Chronic Care Model: A Review
Current Diabetes Reviews Evaluation of LVDD by CCTA with Dual-source CT in Type 2 Diabetes Mellitus Patients
Current Medical Imaging Management of Prehypertension: Current Status and Future Strategies
Current Hypertension Reviews Growing Burden of Diabetes in Sub- Saharan Africa: Contribution of Pesticides ?
Current Diabetes Reviews Statins in Acute Coronary Syndromes
Current Pharmaceutical Design Medications not Intended for Treatment of Dyslipidemias and with a Variable Effect on Lipids
Current Pharmaceutical Design Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults
Current Medicinal Chemistry The Impact of Uncontrolled Hypertension on the Longitudinal Systolic Function of the Left Ventricle
Current Hypertension Reviews Nutrigenomic Analysis of Diet-Gene Interactions on Functional Supplements for Weight Management
Current Genomics The Therapeutic Potential of Rutin for Diabetes: An Update
Mini-Reviews in Medicinal Chemistry Novel Therapeutic Strategy in the Management of COPD: A Systems Medicine Approach
Current Medicinal Chemistry Common Variants in Toll-Like Receptor 4 Confer Susceptibility to Alzheimer’s Disease in a Han Chinese Population
Current Alzheimer Research Can't Always Get What you Want? Try an Indirect Route you Just Might Get What you Need: A Study on Access to Genetic Data by Canadian Life Insurers
Current Pharmacogenomics and Personalized Medicine Controlled Release Inhalable Polymeric Microspheres for Treatment of Pulmonary Arterial Hypertension
Current Pharmaceutical Design Neurohormonal Activation in Ischemic Stroke: Effects of Acute Phase Disturbances on Long-Term Mortality
Current Neurovascular Research Metabolic Syndrome and Diabetic Atherothrombosis: Implications in Vascular Complications
Current Molecular Medicine Estriol Inhibits Dermcidin Isoform-2 Induced Inflammatory Cytokine Expression Via Nitric Oxide Synthesis in Human Neutrophil
Current Molecular Medicine Recent Progress in Pharmacological Research of Antioxidants in Pathological Conditions: Cardiovascular Health
Recent Patents on Anti-Infective Drug Discovery Editorial [Hot topic: Infective Endocarditis (Guest Editor: Ioannis Starakis)]
Infectious Disorders - Drug Targets Atypical Presentation Of Anti-Retroviral Therapy Induced Lactic Acidosis as Acute Right Ventricular Failure And Severe Pulmonary Hypertension
New Emirates Medical Journal