![conference banner](/images/conference-banner.jpeg)
摘要
原发性硬化性胆管炎(PSC)是一种胆道疾病,具有肝发炎以及胆管凋亡反过来导致肝的纤维化、硬化以及功能改变的特点。PSC也与发生胆道癌的风险增加有关。目前为止,PSC的发病机制尚未完全得到了解,尽管与环境因素相关的遗传倾向导致免疫介导的肝损伤。这些知识的匮乏是导致当前大多数治疗失败的原因。与此同时,大量的研究正在评估那些对该疾病进展的阳性影响。本文旨在提供当前以及过去对PSC治疗的方法的综述。
关键词: 原发性硬化性胆管炎,胆汁郁积,发病机制,炎症性肠病,诊断,治疗
Current Drug Targets
Title:Current Targets for Primary Sclerosing Cholangitis
Volume: 18 Issue: 8
关键词: 原发性硬化性胆管炎,胆汁郁积,发病机制,炎症性肠病,诊断,治疗
摘要: Primary sclerosing cholangitis (PSC) is a biliary disease characterized by liver inflammation and death of cholangiocytes which, in turn, drive to fibrosis, cirrhosis and functional alterations of the liver. PSC is also associated with an increased risk of developing cholangiocarcinoma. To date, the etiopathogenesis of PSC is still not completely understood, although a genetic predisposition in association to environmental factors contribute to immune-mediated liver damage. The lack of such knowledge is responsible for the failure of most available therapies. At this time, many studies are evaluating potential approaches that could have a positive impact on the progression of the disease. This review aims to provide a summary of present and past therapeutic approaches for PSC.
Export Options
About this article
Cite this article as:
Current Targets for Primary Sclerosing Cholangitis, Current Drug Targets 2017; 18 (8) . https://dx.doi.org/10.2174/1389450117666160112114152
DOI https://dx.doi.org/10.2174/1389450117666160112114152 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
RNA Molecules in the Treatment of Human Diseases
Messenger and non-coding RNAs, including long and small transcripts, are mediators of gene expression. Gene expression at the RNA level shows significant aberrations in human diseases, including cancer, leukemia, lymphoma, cardiovascular diseases, and neurological disorders. Human transcripts serve either as biomarkers of diagnosis, prognosis, prediction of treatment response, and/or therapy ...read more
Therapeutic Chemical and RNA Design with Artificial Intelligence
Computer-Aided Drug Design (CADD) has emerged as a fundamental component of modern drug discovery. Molecular docking facilitates virtual screening on a large scale through structural simulations. However, traditional CADD approaches face significant limitations, as they can only screen known compounds from existing libraries. PubChem, as the most widely used chemical ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-Cancer Properties of Nigella spp. Essential Oils and their Major Constituents, Thymoquinone and β-Elemene
Current Clinical Pharmacology Review on Novel Carrier System: Liposomes and Proliposomes
Drug Delivery Letters Dual Acting Anti-Inflammatory Drugs
Current Topics in Medicinal Chemistry Angiogenic and Vascular Modulation by Extracellular Matrix Cleavage Products
Current Pharmaceutical Design Role of Dendritic Cell-Derived Cytokines in Immune Regulation
Current Pharmaceutical Design Total Tannin Content and Antidiarrheal Activity of Tecomaria capensis Leaves Extract
The Natural Products Journal Directed Differentiation and Paracrine Mechanisms of Mesenchymal Stem Cells: Potential Implications for Tendon Repair and Regeneration
Current Stem Cell Research & Therapy Heparin-Binding Proteins (Chemokines and Defensins) and their Complexes with Glycosaminoglycans from the Solution NMR Perspective
Current Protein & Peptide Science Better Targeting Melanoma: Options Beyond Surgery and Conventional Chemotherapy
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Chikungunya Infection and Immunity: An Overview
Current Immunology Reviews (Discontinued) Relevance of Postprandial Lipemia in Metabolic Syndrome
Current Vascular Pharmacology Hypothyroidism and Nephrotic Syndrome: Why, When and How to Treat
Current Vascular Pharmacology Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction
Current Pharmaceutical Design Cannabidiol as a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development
Current Pharmacogenomics and Personalized Medicine Annexins in the Central Nervous System: Are they Neuroprotective or Proapoptotic Agents?
Medicinal Chemistry Reviews - Online (Discontinued) Meet the Editorial Board
Mini-Reviews in Medicinal Chemistry Review on Mucormycosis: Pathogenesis, Epidemiology, Microbiology and Diagnosis
Infectious Disorders - Drug Targets Alterations in Glucose Metabolism on Cognition: A Possible Link Between Diabetes and Dementia
Current Pharmaceutical Design Health Effects of Vaccinium myrtillus L.: Evaluation of Efficacy and Technological Strategies for Preservation of Active Ingredients
Mini-Reviews in Medicinal Chemistry Colon as Target for Drug Delivery
Current Drug Therapy