原发性硬化性胆管炎的靶点

Title:Current Targets for Primary Sclerosing Cholangitis

Volume: 18 Issue: 8

关键词: 原发性硬化性胆管炎，胆汁郁积，发病机制，炎症性肠病，诊断，治疗

摘要: Primary sclerosing cholangitis (PSC) is a biliary disease characterized by liver inflammation and death of cholangiocytes which, in turn, drive to fibrosis, cirrhosis and functional alterations of the liver. PSC is also associated with an increased risk of developing cholangiocarcinoma. To date, the etiopathogenesis of PSC is still not completely understood, although a genetic predisposition in association to environmental factors contribute to immune-mediated liver damage. The lack of such knowledge is responsible for the failure of most available therapies. At this time, many studies are evaluating potential approaches that could have a positive impact on the progression of the disease. This review aims to provide a summary of present and past therapeutic approaches for PSC.

Cite this article as:

Current Targets for Primary Sclerosing Cholangitis, Current Drug Targets 2017; 18 (8) . https://dx.doi.org/10.2174/1389450117666160112114152