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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Nutraceuticals against Neurodegeneration: A Mechanistic Insight

Author(s): Vivekkumar P. Dadhania, Priyanka P. Trivedi, Ajit Vikram and Durga Nand Tripathi

Volume 14, Issue 6, 2016

Page: [627 - 640] Pages: 14

DOI: 10.2174/1570159X14666160104142223

Price: $65


The mechanisms underlying neurodegenerative disorders are complex and multifactorial; however, accumulating evidences suggest few common shared pathways. These common pathways include mitochondrial dysfunction, intracellular Ca2+ overload, oxidative stress and inflammation. Often multiple pathways co-exist, and therefore limit the benefits of therapeutic interventions. Nutraceuticals have recently gained importance owing to their multifaceted effects. These food-based approaches are believed to target multiple pathways in a slow but more physiological manner without causing severe adverse effects. Available information strongly supports the notion that apart from preventing the onset of neuronal damage, nutraceuticals can potentially attenuate the continued progression of neuronal destruction. In this article, we i) review the common pathways involved in the pathogenesis of the toxicants-induced neurotoxicity and neurodegenerative disorders with special emphasis on Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Multiple sclerosis (MS) and Amyotrophic lateral sclerosis (ALS), and ii) summarize current research advancements on the effects of nutraceuticals against these detrimental pathways.

Keywords: Neurodegeneration, mitochondria, calcium, oxidative stress, inflammation, nutraceuticals.

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