![conference banner](/images/conference-banner.jpeg)
摘要
许多疾病影响呼吸道,喷雾剂已被广泛认为是一种合适的非侵入性的传递方法。该方法使促使药物集中于肺部,因此该方法存在一些限制和副作用。由于存在障碍如特定的呼吸运动、粘液或表面活性剂的存在以及粘液纤毛清除,活性药物成分的气雾传导极具挑战。纳米药物如脂质体、胶束或纳米粒子能提高生物利用度,有利于细胞内的特定药物的渗透到肺组织。本文着重细胞阻碍与喷雾剂的设计、特征和对气道解剖的逐步适应。然后,喷雾制剂制剂目前得到了临床批准或者依据包囊药物正在进行临床试验。最后,对处于临床前研究的较合适的喷雾制剂进行了的详细说明。
关键词: Bysta纳米药物,雾化吸入,吸入,抗生素、化疗、质粒。
Current Gene Therapy
Title:Challenges and Successes Using Nanomedicines for Aerosol Delivery to the Airways
Volume: 16 Issue: 1
Author(s): P. Resnier, A. Mottais, Y. Sibiril T. Le Gall and T. Montier
Affiliation:
关键词: Bysta纳米药物,雾化吸入,吸入,抗生素、化疗、质粒。
摘要: Numerous diseases affect the respiratory tract and the aerosol administration has been widely considered as an adapted and non-invasive method for local delivery. This pathway induces a lung concentration and thus also limits, systemic side effects. However, aerosol delivery of active pharmaceutical ingredients represents a real challenge, due to numerous obstacles such as the specific respiratory movement, the presence of mucus or surfactant, and the mucociliary clearance. Nanomedicines, such as liposomes, micelles or nanoparticles, offer the possibility to increase bioavailability and favor intracellular penetration of specific drugs into lung tissue. This review focuses on the description of aerosol formulations and cellular barriers including design, characteristics and progressive adaptation to airways anatomy. Then, aerosolized formulations currently clinically approved, or in clinical trial are summarized according to the encapsulated drug. In a final section, promising aerosol formulations in pre-clinical studies are detailed.
Export Options
About this article
Cite this article as:
P. Resnier, A. Mottais, Y. Sibiril T. Le Gall and T. Montier , Challenges and Successes Using Nanomedicines for Aerosol Delivery to the Airways, Current Gene Therapy 2016; 16 (1) . https://dx.doi.org/10.2174/1566523216666160104142013
DOI https://dx.doi.org/10.2174/1566523216666160104142013 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Melatonin Signaling in Health and Disease
Melatonin regulates a multitude of physiological functions, including circadian rhythms, acting as a scavenger of free radicals, an anti-inflammatory agent, a modulator of mitochondrial homeostasis, an antioxidant, and an enhancer of nitric oxide bioavailability. AANAT is the rate-limiting enzyme responsible for converting serotonin to NAS, further converted to melatonin by ...read more
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Reverse Screening Bioinformatics Approach to Identify Potential Anti Breast Cancer Targets Using Thymoquinone from Neutraceuticals Black Cumin Oil
Anti-Cancer Agents in Medicinal Chemistry TGF-β Pathway as a Therapeutic Target in Bone Metastases
Current Pharmaceutical Design MicroRNAs and the Response of Prostate Cancer to Anti-Cancer Drugs
Current Drug Targets MicroRNA Regulation of TRAIL in Renal Carcinoma: Tiny Juggernauts at Work
Current Molecular Pharmacology Therapeutics Based on microRNA: A New Approach for Liver Cancer
Current Genomics Anti-cancer and Anti-angiogenic Properties of Various Natural Pentacyclic Tri-terpenoids and Some of their Chemical Derivatives
Current Organic Chemistry Advances in α(v)β(3) Integrin-Targeting Cancer Therapy and Imaging with Radiolabeled RGD Peptides
Current Radiopharmaceuticals Arsenic Trioxide Exerts Anti-lung Cancer Activity by Inhibiting Angiogenesis
Current Cancer Drug Targets Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder
Current Medicinal Chemistry Pulmonary Drug Delivery System: A Novel Approach for Drug Delivery
Current Drug Therapy Chemokines and Chemokine Receptors: Potential Therapeutic Targets in Multiple Sclerosis
Current Drug Targets - Inflammation & Allergy Network Pharmacology-based Prediction and Verification of Shikonin for Treating Colorectal Cancer
Recent Patents on Anti-Cancer Drug Discovery Base Excision Repair: Contribution to Tumorigenesis and Target in Anticancer Treatment Paradigms
Current Medicinal Chemistry The Bioreactor: A Powerful Tool for Large-Scale Culture of Animal Cells
Current Pharmaceutical Biotechnology Recent Patents Relating to Tumor Suppressor Genes
Recent Patents on DNA & Gene Sequences Effect-based Hazard Identification of House Dust by In Vitro Assays Detecting Dioxin-like Compounds, Thyroid and Reproductive Toxicants
Current Organic Chemistry Potentials of Hydrogels in Cancer Therapy
Current Cancer Therapy Reviews Current Drugs and their Therapeutic Targets for Hypoxia-inducible Factors in Cancer
Current Protein & Peptide Science Triggering PIK3CA Mutations in PI3K/Akt/mTOR Axis: Exploration of Newer Inhibitors and Rational Preventive Strategies
Current Pharmaceutical Design Vitamin D Analogs as Modulators of Vitamin D Receptor Action
Current Topics in Medicinal Chemistry