摘要
内皮功能障碍的主要特点是受损的内皮依赖性转导机制与血管舒张,作为一个结果的内皮依赖性舒张因子的释放减少,主要是一氧化氮,以及增强氧化应激,增加炎症和占主导地位的血管作用产生的内皮细胞衍生的收缩因子。目前的数据有力地表明,不同类型的肾功能受损的病理发展与进一步的进展到肾功能衰竭,包括显着的血管改变与血管内皮功能障碍。按照,这一科学领域代表了一个推进领域的调查,涉及不同的生物标志物与肾功能受损的内皮功能障碍,以及新的信息,可以提供一个更全面的了解,在肾脏疾病的血管内皮功能障碍的临床结果。关于引用事实,这篇文章的目的是审查最新的数据相关的血管内皮功能障碍和肾功能衰竭的选择从2010至2015的相关文章。
关键词: 内皮功能障碍,肾功能衰竭,肾脏疾病,肾损伤,心肾综合征、糖尿病肾病、移植失败,肾小球硬化。
Current Medicinal Chemistry
Title:Endothelial Dysfunction in Renal Failure: Current Update
Volume: 23 Issue: 19
Author(s): Miroslav Radenkovic, Marko Stojanovic, Milica Prostran
Affiliation:
关键词: 内皮功能障碍,肾功能衰竭,肾脏疾病,肾损伤,心肾综合征、糖尿病肾病、移植失败,肾小球硬化。
摘要: Endothelial dysfunction is principally characterized by impaired endothelium– dependent transduction mechanisms related to vascular relaxation, as an outcome of decreased release of endothelium–derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium–derived contracting factors. Current data strongly suggest that pathological development of different types of kidney impairment with further progression to renal failure includes notable vascular changes associated with endothelial dysfunction. In accordance, this scientific field represents an advancing area of investigation, involving different biomarkers of endothelial dysfunction linked to renal impairment, as well as clinical findings with new information that can provide a more comprehensive understanding of the role of endothelial dysfunction in kidney disease. With regards to quoted facts, the aim of this article was to review the latest data related to endothelial dysfunction and renal failure by selection of relevant articles released from 2010 to 2015.
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Cite this article as:
Miroslav Radenkovic, Marko Stojanovic, Milica Prostran , Endothelial Dysfunction in Renal Failure: Current Update, Current Medicinal Chemistry 2016; 23 (19) . https://dx.doi.org/10.2174/0929867323666151231095126
DOI https://dx.doi.org/10.2174/0929867323666151231095126 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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