肾功能衰竭的内皮功能障碍：目前的更新

Title:Endothelial Dysfunction in Renal Failure: Current Update

Volume: 23 Issue: 19

Author(s): Miroslav Radenkovic, Marko Stojanovic, Milica Prostran

Affiliation:

关键词: 内皮功能障碍，肾功能衰竭，肾脏疾病，肾损伤，心肾综合征、糖尿病肾病、移植失败，肾小球硬化。

摘要: Endothelial dysfunction is principally characterized by impaired endothelium– dependent transduction mechanisms related to vascular relaxation, as an outcome of decreased release of endothelium–derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium–derived contracting factors. Current data strongly suggest that pathological development of different types of kidney impairment with further progression to renal failure includes notable vascular changes associated with endothelial dysfunction. In accordance, this scientific field represents an advancing area of investigation, involving different biomarkers of endothelial dysfunction linked to renal impairment, as well as clinical findings with new information that can provide a more comprehensive understanding of the role of endothelial dysfunction in kidney disease. With regards to quoted facts, the aim of this article was to review the latest data related to endothelial dysfunction and renal failure by selection of relevant articles released from 2010 to 2015.

Cite this article as:

Miroslav Radenkovic, Marko Stojanovic, Milica Prostran , Endothelial Dysfunction in Renal Failure: Current Update, Current Medicinal Chemistry 2016; 23 (19) . https://dx.doi.org/10.2174/0929867323666151231095126