Title:Jade-1: its structure, regulation and functions in the renal cancer.
Volume: 16
Issue: 1
Author(s): Y.-C. Zhang, W.-Q. Du, R.-Y. Zhang, J.-N. Zheng and D.-S. Pei
Affiliation:
Keywords:
Jade-1, pVHL, renal cancer, renal cyst, HAT, β-catenin.
Abstract: Jade-1 is originally identified by the yeast two-hybrid system as a
protein partner of von Hippel-Lindau (pVHL) tumor suppressor, a well-known renal tumor suppressor. In
cellular signaling pathways, many upstream Jade-1 regulators, such as pVHL, CK1α, PC1, and NPHP4, can
control its activity by stabilization, phosphorylation, and nuclear translocation. Numerous downstream effectors,
including β-catenin, AKT, p21, and Bcl-2, are well modulated by Jade-1, which mainly regulates cell
proliferation and apoptosis. Jade-1 is also deemed to be a candidate of transcriptional co-activator associated
with histone acetyltransferase (HAT) activity. This review focuses on the anticancer role of Jade-1 in clear cell
renal carcinoma and the inhibitory effect of Jade-1 on cystic renal diseases. This review aims to provide a
basis of disease prevention or therapy.
