摘要
癌症发展的复杂病理需要相应复杂的治疗。个人单靶向药物的传统的应用不能以持久的疗效和耐受副作用充分地治疗癌症。因此,药物的协同作用是一个极具希望加强疗效、克服毒性和优化安全性的方式。中国的草药(CHMs)一直被用来作此类协同作用。因此,我们总结了联用中草药用于癌症的治疗以及在化疗中提高疗效,减少副作用, 免疫调节,以及消除耐药性方面中所扮演的角色。我们的结论支持进一步以科学为基础的用于癌症治疗的整体模式的发展。
关键词: 癌症治疗、中药、耐药性、效应、免疫力、副作用、协同联用。
Current Cancer Drug Targets
Title:Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer
Volume: 16 Issue: 4
Author(s): Xue-Qing Hu, Yang Sun, Eric Lau, Ming Zhao, Shi-Bing Su
Affiliation:
关键词: 癌症治疗、中药、耐药性、效应、免疫力、副作用、协同联用。
摘要: The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms of enhancing efficacy, reducing side effects, immune modulation, as well as abrogating drug resistance. Our conclusions support the development of further science-based holistic modalities for cancer care.
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Cite this article as:
Xue-Qing Hu, Yang Sun, Eric Lau, Ming Zhao, Shi-Bing Su , Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer, Current Cancer Drug Targets 2016; 16 (4) . https://dx.doi.org/10.2174/1568009616666151207105851
DOI https://dx.doi.org/10.2174/1568009616666151207105851 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process of exploring and investigating the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
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