Title:LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals
Volume: 14
Issue: 2
Author(s): Miryam Nava Catorce and Goar Gevorkian
Affiliation:
Keywords:
Astrocytes, LPS, microglia, neurodegeneration, neuroinflammation, nutraceuticals.
Abstract: Neuroinflammation is an important feature in the pathogenesis and progression of
neurodegenerative diseases such as Alzheimer´s disease (AD), Parkinson´s disease (PD), frontotemporal
dementia and amyotrophic lateral sclerosis. Based on current knowledge in the field, suggesting that
targeting peripheral inflammation could be a promising additional treatment/prevention approach for
neurodegenerative diseases, drugs and natural products with anti-inflammatory properties have been
evaluated in animal models of neuroinflammation and neurodegeneration. In this review, we provide
an extensive analysis of one of the most important and widely-used animal models of peripherally
induced neuroinflammation and neurodegeneration - lipopolysaccharide (LPS)-treated mice, and address the data
reproducibility in published research. We also summarize briefly basic features of various natural products, nutraceuticals,
with known anti-inflammatory effects and present an overview of data on their therapeutic potential for reducing
neuroinflammation in LPS-treated mice.
