Title:The Coronin Family and Human Disease
Volume: 17
Issue: 6
Author(s): Xiaolong Liu, Yunzhen Gao, Xiao Lin, Lin Li, Xiao Han and Jingfeng Liu
Affiliation:
Keywords:
Coronin, human disease, cAMP signaling, cancer, WD repeats, actin associated protein.
Abstract: The Coronin family is one of the WD-repeat domain containing families that are diverse in
both of their structures and functions. The first coronin was identified in the cytoskeleton composition
of Dictyostelium discoideum, which was discovered to regulate the actin functions. So far, 723 coronins
have been identified throughout the eukaryotic kingdom by bioinformatics analysis in 358 species.
In mammals, 7 coronins have been identified to date, which are named through Coronin 1 to Coronin 7; all of these isoforms
contain two structurally conservational region: a 7-bladed β-propeller scaffold in N-terminal and a C-terminal variable
coiled coil domain. Although some studies were showing that mammalian coronins have regulated the actin dynamics,
recently many other functions such as calcium signaling regulation, cAMP signaling regulation, have been also reported
beyond the actin modulation. Furthermore, many diseases have been found to be extensively associated with the
abnormal expression of coronins, such as auto-immunity, bacterial and virus infection, neuronal behavior disorder and
cancer. In this review, we would like to systematically discuss the recent progresses of mammalian coronins and associated
diseases, as well as possible underlying molecular mechanisms.
