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Abstract
It has long been known that cannabinoids can alter perception and cognitive function. In this review article, we first discuss the current knowledge of both plant-derived and synthetic cannabinoid effects on learning and memory formation in animals with a particular emphasis on spatial mapping. It appears that stimulation of the cannabinoid receptors in the brain is detrimental to spatial learning, and recent advances suggest that working memory is particularly vunerable and in some cases the involvement of the cannabinoid system in memory consolidation. Most of these effects are mediated by CB1 receptors, and blockade of these receptors can, under certain conditions enhance learning. In the second part, we investigate whether cannabinoid effects can be explained in terms of modulation of other transmitter systems. Since CB1 is G-protein-coupled and predominantly presynaptically localised, the primary effect may lie in a down / up-regulation of other transmitters, resulting in memory deficits. Such an analysis proved useful as it revealed that modulation of the noradrenergic and cholinergic system is readily able to explain deficits reported in memory consolidation, while cholinergic, dopaminergic, and GABAergic regulation may explain working memory deficits.
Keywords: cb1 receptors, spatial learning and memory, cholinergic system, glutamate, cholecystokinin, serotonin, dopamine
Current Neuropharmacology
Title: Cannabinoid Function in Spatial Learning: An Update
Volume: 2 Issue: 1
Author(s): L. Robinson and G. Riedel
Affiliation:
Keywords: cb1 receptors, spatial learning and memory, cholinergic system, glutamate, cholecystokinin, serotonin, dopamine
Abstract: It has long been known that cannabinoids can alter perception and cognitive function. In this review article, we first discuss the current knowledge of both plant-derived and synthetic cannabinoid effects on learning and memory formation in animals with a particular emphasis on spatial mapping. It appears that stimulation of the cannabinoid receptors in the brain is detrimental to spatial learning, and recent advances suggest that working memory is particularly vunerable and in some cases the involvement of the cannabinoid system in memory consolidation. Most of these effects are mediated by CB1 receptors, and blockade of these receptors can, under certain conditions enhance learning. In the second part, we investigate whether cannabinoid effects can be explained in terms of modulation of other transmitter systems. Since CB1 is G-protein-coupled and predominantly presynaptically localised, the primary effect may lie in a down / up-regulation of other transmitters, resulting in memory deficits. Such an analysis proved useful as it revealed that modulation of the noradrenergic and cholinergic system is readily able to explain deficits reported in memory consolidation, while cholinergic, dopaminergic, and GABAergic regulation may explain working memory deficits.
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Cite this article as:
Robinson L. and Riedel G., Cannabinoid Function in Spatial Learning: An Update, Current Neuropharmacology 2004; 2 (1) . https://dx.doi.org/10.2174/1570159043476909
DOI https://dx.doi.org/10.2174/1570159043476909 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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