Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A

Title:Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A

Volume: 15 Issue: 10

Author(s): L. -L. Gong, D. W. -C. Li, Y. -Z. Liu, W. -B. Liu, Z. -G. Chen, T. -H. Yang, R. -L. Qi, S. Huang, L. Zhang, L. Wang, W. -F. Hu, X. -H. Hu, W. -K. Ji, Z. -F. Wang, Q. Nie, Z. -X. Huang, X. -D. Gong and Y. Yang

Affiliation:

Keywords: Serine/threonine phosphatases-1 and -2A, eye development, lens differentiation, developmental apoptosis.

Abstract: The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

Cite this article as:

Gong -L. L., -C. Li W. D., Liu -Z. Y., Liu -B. W., Chen -G. Z., Yang -H. T., Qi -L. R., Huang S., Zhang L., Wang L., Hu -F. W., Hu -H. X., Ji -K. W., Wang -F. Z., Nie Q., Huang -X. Z., Gong -D. X. and Yang Y., Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A, Current Molecular Medicine 2015; 15 (10) . https://dx.doi.org/10.2174/156652401510151125125127