Title:Targeted Drug Delivery System for Platinum-based Anticancer Drugs
Volume: 16
Issue: 11
Author(s): Chuanzhu Gao, Yan Zhang, Ji Chen, Tianshuai Wang, Yunxu Qian, Bo Yang, Peng Dong and Yingjie Zhang
Affiliation:
Keywords:
Anticancer, Drugs-macrocyclic compounds system, Nanoparticle drug system, Platinum-based drugs, Polymerdrug
system, Review, Targeted drug delivery system.
Abstract: Platinum-based (Pt-based) anticancer drugs have been recognised as one of the most
effective drugs for clinical treatment of malignant tumors due to its unique mechanism of action and
broad range of anticancer spectrum. But, there are still some limitations such as side effects, drug
resistance/cross resistance, no-specific targeting, becoming obstacles to restrict its expanding of
clinical application. Targeted drug delivery system (TDDS) is a promising strategy for the research of
novel Pt-based anticancer drugs. A variety of TDDS have been explored to improve the antitumor activity of Pt-based
drugs such as nanoparticle drug systems, polymer-drug systems, drugs-macrocyclic compounds systems, etc. The review
concentrates on recent development of various targeted drug delivery techniques, which could provide more opportunities
for the development of Pt-based drugs with better efficiency, lower toxicity and less resistance.
