Abstract
With ever-increasing drug resistant clinical isolates, novel antibiotics with new targets are urgently needed. Tuberculosis, caused by Mycobacterium tuberculosis, showed formidable antibiotics resistance. InhA, the enoyl-acyl carrier protein (ACP) reductase involved in the type II fatty acid synthesis pathway (FASII) in Mycobacterium tuberculosis, represents an appealing target for the development of new anti-tuberculosis (TB) agents. Inhibitors against InhA might be ideal lead or antibiotics. The latest development of InhA inhibitors is summarized in this paper.
Keywords: Drug discovery, drug resistance, enoyl-ACP reductase, InhA, isoniazid, tuberculosis.
Letters in Drug Design & Discovery
Title:Progress on the Discovery of Inhibitors of InhA, the FAS II Enoyl-ACP Reductase TB Drug Discovery Targeted on InhA
Volume: 13 Issue: 6
Author(s): Yi Zhang, Longxiang Xie and Jianping Xie
Affiliation:
Keywords: Drug discovery, drug resistance, enoyl-ACP reductase, InhA, isoniazid, tuberculosis.
Abstract: With ever-increasing drug resistant clinical isolates, novel antibiotics with new targets are urgently needed. Tuberculosis, caused by Mycobacterium tuberculosis, showed formidable antibiotics resistance. InhA, the enoyl-acyl carrier protein (ACP) reductase involved in the type II fatty acid synthesis pathway (FASII) in Mycobacterium tuberculosis, represents an appealing target for the development of new anti-tuberculosis (TB) agents. Inhibitors against InhA might be ideal lead or antibiotics. The latest development of InhA inhibitors is summarized in this paper.
Export Options
About this article
Cite this article as:
Zhang Yi, Xie Longxiang and Xie Jianping, Progress on the Discovery of Inhibitors of InhA, the FAS II Enoyl-ACP Reductase TB Drug Discovery Targeted on InhA, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/1570180812666151016205422
DOI https://dx.doi.org/10.2174/1570180812666151016205422 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
NMR Assisted Antimicrobial Peptide Designing: Structure Based Modifications and Functional Correlation of a Designed Peptide VG16KRKP
Current Medicinal Chemistry Editorial [Hot Topic: Structure Based Drug Design (Guest Editor: K.V. Radha Kishan)]
Current Protein & Peptide Science Recent Patents of Gene Sequences Relative to DNA Polymerases
Recent Patents on DNA & Gene Sequences HIV Vaccine Efficacy and Immune Correlates of Risk
Current HIV Research An Effective Approach of CT Lung Segmentation Using Possibilistic Fuzzy C-Means Algorithm and Classification of Lung Cancer Cells with the Aid of Soft Computing Techniques
Current Medical Imaging Treasures Hunt in Old Mines: Terminalia chebula-Based Traditional Herbal Medicinal Products
The Natural Products Journal New Antifolate Inhibitors for Mycobacterium avium
Medicinal Chemistry Synthesis and Biological Evaluation of Naphthalene-1,4-dione Derivatives as Potent Antimycobacterial Agents
Medicinal Chemistry Meet the Editorial Board Member
Current Pharmaceutical Biotechnology Th1-mediated Pathology in Mouse Models of Human Disease is Ameliorated by Concurrent Th2 Responses to Parasite Antigens
Current Topics in Medicinal Chemistry Therapeutic Journey and Recent Advances in the Synthesis of Coumarin Derivatives
Mini-Reviews in Medicinal Chemistry New Chemotherapy and Immunotherapy for Tuberculosis
Current Respiratory Medicine Reviews Endophytic Fungi in the Fight Against Neglected Tropical Diseases
Mini-Reviews in Medicinal Chemistry MolDock Applied to Structure-Based Virtual Screening
Current Drug Targets WITHDRAWN: Current Trends in the Detection of Biological Proteins and Immunological Assays using Graphene Quantum Dots
Current Analytical Chemistry Ferrocene and Organotin (IV) Conjugates Containing Amino Acids and Peptides: A Promising Strategy for Searching New Therapeutic and Diagnostic Tools
Current Organic Chemistry Quinoline: An Attractive Scaffold in Drug Design
Mini-Reviews in Medicinal Chemistry Recent Advancement in Synthesis and Bioactivities of 1,3,4-Oxadiazole
Current Organic Synthesis Understanding the Structure, Activity and Inhibition of Chorismate Synthase from Mycobacterium tuberculosis
Current Medicinal Chemistry Synthesis, Computational Analysis, Antimicrobial, Antioxidant, Trypan Blue Exclusion Assay, β-hematin Assay and Anti-inflammatory Studies of some Hydrazones (Part-I)
Current Computer-Aided Drug Design